机构：[1]State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology (CAS), Guangzhou, China,[2]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China,[3]The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China,[4]International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China,深圳市中医院深圳医学信息中心[5]Institute of Higher Education, Guangzhou University of Chinese Medicine, Guangzhou, China
Inflammatory bowel disease (IBD) is a chronic immune-related disease mainly caused by the disequilibrium of T helper (Th) cell paradigm? Pogostone (PO) is one of the major chemical constituents of Pogostemon cablin (Blanco) Benth. The present study aims to investigate the potential benefit of PO against IBD in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis model. PO treatment by enema significantly brought down the disease activity index (DAI) of the TNBS-challenged rats, which was manifested by the ameliorated inflammatory features including ulceration, adhesion, and edema. Hematoxylin-eosin (HE) staining and immunohistochemistry analysis showed that PO effectively relived colon damage by restoring epithelium, and more importantly, by inhibiting the infiltration of pro-inflammatory Th1 and Th17 cells in the colon. Additionally, PO inhibited the activity of myeloperoxidase and secretion of inflammatory cytokines including IFN-γ, IL-12p70, IL-17A, and IL-10. Together with our previous findings, the present data indicated that the anti-IBD effect of PO probably related to its direct inhibition on Th cell proliferation and suppression of the cytokines secretion. These results highlighted the potential of PO as a promising candidate to relieve IBD.
基金：
This work was supported by grants from Hong Kong, Macao
and Taiwan Science and Technology Cooperation Program
of China (No. 2014DFH30010), Science and Technology
Major Project of Guangdong Province (2013A022100001),
Science and Technology Planning Project of Guangdong
Province, China (Nos. 2013B090600007 and 2013B090800052
and 2013B090600026), Guangdong International Cooperation
Project (No. 2013508102016).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|2 区药学
最新[2025]版：
大类|3 区医学
小类|3 区药学
第一作者：
第一作者机构：[1]State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology (CAS), Guangzhou, China,[2]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Jiyan Su,Cailan Li,Xiuting Yu,et al.Protective Effect of Pogostone on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis via Inhibition of T Helper Cell.[J].Frontiers in pharmacology.2017,8:829.doi:10.3389/fphar.2017.00829.
APA：
Jiyan Su,Cailan Li,Xiuting Yu,Guanghua Yang,Jianhua Deng...&Xiaoping Lai.(2017).Protective Effect of Pogostone on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis via Inhibition of T Helper Cell..Frontiers in pharmacology,8,
MLA：
Jiyan Su,et al."Protective Effect of Pogostone on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis via Inhibition of T Helper Cell.".Frontiers in pharmacology 8.(2017):829
