机构：[1]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, China广东省中医院[2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China广东省中医院[3]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510380, China广东省中医院[4]Guangdong University of Technology, Guangzhou, Guangdong 510380, China
Psoriasis is a T cells mediated chronic skin inflammation in which helper T (Th) cells play in critical roles in its pathogenesis. Taxifolin (TXL) has been discovered to exert various pharmacological activities. In this study, we wished to observe whether TXL had potential activities on psoriasis, and how it works. We found that TXL can inhibit LPS-induced abnormal proliferation in Hacat cell line, ant also significantly alleviate the IMQ-induced psoriasis in BALB/c mice, comparing with the control group. Although TXL has no significant effects on the ratio of total T cells in skin draining lymph nodes (SDLN), it decreases the ratio of pro-inflammatory Th1 and Th17 cells, both in skin lesions and SDLN. Our results also disclosed that TXL may regulate Th cells differentiation by inhibiting the transcript factors, including T-bet, GATA-3 and ROR gamma t. Further data show that TXL can inhibit Notch1 and Jak2/Stat3 signal pathways. In summary, TXL may be able to treat psoriasis by regulating Th cells differentiation via inhibiting Notch1 and Jak2/Stat3 pathways.
基金：
Scientific Research Projects of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81703778]; Specific Research Found for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2018MJ04]; Natural science foundation of Guangdong provinceNational Natural Science Foundation of Guangdong Province [2017A030313733]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2018]版：
Q1PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, China[2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China[3]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510380, China
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, China[2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China[3]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510380, China[*1]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, China
推荐引用方式(GB/T 7714)：
Yuan Xiaohong,Li Ning,Zhang Miaomiao,et al.Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways[J].BIOMEDICINE & PHARMACOTHERAPY.2020,123:doi:10.1016/j.biopha.2019.109747.
APA：
Yuan, Xiaohong,Li, Ning,Zhang, Miaomiao,Lu, Chuanjian,Du, Zhiyun...&Wu, Dinghong.(2020).Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways.BIOMEDICINE & PHARMACOTHERAPY,123,
MLA：
Yuan, Xiaohong,et al."Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways".BIOMEDICINE & PHARMACOTHERAPY 123.(2020)
