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Comparison of neutrophil functions between two strains of inbred mice.

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机构： [1]Department of Oral Biology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055 Guang Zhou [2]Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055 Guang Zhou, [3]Affiliated Hospital of Shandong, University of Traditional Chinese Medicine, 16369 Jingshi Road, Jinan, 250101 Shandong Province, China [4]Faculty of Dentistry, University of Toronto, Toronto, ON M5S, Canada

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关键词： neutrophil Rac1 chemotaxis NADPH oxidase neutrophil extracellular trap

摘要：

In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH mice exhibited weaker Rac1 expression and a slower chemotactic gradient than BALB/c mice. Furthermore, PMA- or fMLP-stimulated neutrophils from CBA/CaH mice generated much less superoxide and NETs than similarly stimulated neutrophils from BALB/c mice. These findings suggest that neutrophils from BALB/c mice are functionally more efficient than those from CBA/CaH mice. © 2016 The Societies and John Wiley & Sons Australia, Ltd.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区微生物学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区微生物学

第一作者：

第一作者机构： [1]Department of Oral Biology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055 Guang Zhou [2]Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055 Guang Zhou,

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通讯作者：

通讯机构： [1]Department of Oral Biology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055 Guang Zhou [2]Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055 Guang Zhou, [*1]Department of Oral Biology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, Guangzhou 510055, China.

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