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Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.

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机构： [1]Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong, China [2]Center for Neuroscience, Shantou University Medical College, Shantou 515041, Guangdong, China [3]Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

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关键词： Glioma Quercetin Apoptosis Matrix metallopeptidase 9 (MMP-9) p-ERK p-AKT

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Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medicinal herb, is an important flavonoid and has anti-cancer activity. Here, we evaluated whether quercetin could inhibit glioma cell viability and migration and promote apoptosis. The treatment of U87-MG glioblastoma and U251 and SHG44 glioma cell lines with different concentrations of quercetin inhibited cell viability in a dose-dependent manner. Wound healing assays indicated that quercetin significantly decreased glioma cell migration. β-galactosidase staining, DNA staining and Annexin V-EGF/PI double staining assays demonstrated that quercetin promoted cell senescence and apoptosis. In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment. Therefore, we conclude that quercetin might inhibit the viability and migration and promote the senescence and apoptosis of glioma cells by suppressing the Ras/MAPK/ERK and PI3K/AKT signalling pathways. Quercetin might be a potential candidate for the clinical treatment of glioma. Copyright © 2014 Elsevier Ltd. All rights reserved.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 4 区生化与分子生物学 4 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区生化与分子生物学 3 区神经科学

第一作者：

第一作者机构： [1]Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong, China [2]Center for Neuroscience, Shantou University Medical College, Shantou 515041, Guangdong, China

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通讯机构： [1]Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong, China [2]Center for Neuroscience, Shantou University Medical College, Shantou 515041, Guangdong, China [*1]Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, 7 Rao Ping Road, Shantou 515041, Guangdong, China. [*2]Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou 515041, Guangdong, China.

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