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TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2 axis in glioma.

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机构： [1]Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. [2]Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China. [3]Department of neurosurgery ward 6, Guangdong 999 Brain Hospital, Guangzhou 510510, China. [4]Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China. [5]Department of Clinical Laboratory, Guangzhou Twelfth People's Hospital, Guangzhou 510420, China. [6]Department of Vascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China. [7]Hui Qiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. [8]Laboratory Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China. [9]Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510000, China.

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关键词： TTDA p53 apoptosis glioma

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The trichothiodystrophy group A protein (TTDA) functions in nucleotide excision repair and basal transcription. TTDA plays a role in cancers and serves as a prognostic and predictive factor in high-grade serous ovarian cancer; however, its role in human glioma remains unknown. Here, we found that TTDA was overexpressed in glioma tissues. In vitro experiments revealed that TTDA overexpression inhibited apoptosis of glioma cells and promoted cell growth, whereas knockdown of TTDA had the opposite effect. Increased TTDA expression significantly decreased the Bax/Bcl2 ratio and the level of cleaved-caspase3. TTDA interacted with the p53 gene at the -1959 bp and -1530 bp region and regulated its transcription, leading to inhibition of the p53-Bax/Bcl2 mitochondrial apoptosis pathway in glioma cells. These results indicate that TTDA is an upstream regulator of p53-mediated apoptosis and acts as an oncogene, suggesting its value as a potential molecular target for the diagnosis and treatment of glioma. Copyright © 2020. Published by Elsevier Inc.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区神经科学

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Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 4.6 最新[2023版] 4.8 最新五年平均 4.562 出版当年[2018版] 4.682 出版当年五年平均 4.483 出版前一年[2017版] 4.691 出版后一年[2019版]

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第一作者机构： [1]Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

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通讯机构： [1]Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. [7]Hui Qiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. [8]Laboratory Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China. [9]Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510000, China. [*1]Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. [*2]Hui Qiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

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