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Enhancement of osteogenesis post-splenectomy does not attenuate bone loss in ovariectomized rats.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Sun Dawei[1,2] * ; Zheng Xiaochen[1,3] * ; Chen Yuhui[1] * ; Jia Chunhong[4] ; Xu Song[1,4] ; Lin Chuangxin[1] ; Zhang Pei[5] ; Zhang Zhongmin[1] ; Cai Daozhang[1] ; Jin Dadi[1] ; Zhang Baiyu[6] ; Bai Xiaochun[1,4] ;
机构： [1]Department of Orthopedics, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510665, China, [2]Department of Orthopedics & Microsurgery, Guangdong No. 2 Provincial People’s Hospital, Guangzhou 510317, China, [3]Department of Orthopedics, the Second Affiliated Hospital of Luohe Medical College, Luohe 462300, China, [4]Department of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China, [5]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China, [6]Department of Rehabilitation Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
出处：
DOI： 10.1002/jor.22825
ISSN：

关键词： splenectomy osteogenesis ovariectomy osteoporosis osteoclastogenesis

摘要：
The roles of different immune cell populations and cytokines in bone metabolism have been extensively investigated. However, the influence of whole immune organ removal on osteopathology remains unknown. In the current study, we investigated the effects of splenectomy on bone metabolism and microarchitecture in rats with or without concurrent ovariectomy. Ovariectomized (OVX) rats were used as osteoporosis model. Sixty 12-week-old female rats were randomized into 4 groups (n = 15): sham, splenectomized (SP), ovariectomized, as well as ovariectomized and splenectomized (OVX + SP). Bone microarchitecture was assessed by micro CT analysis at 4 week and 12 week post-operation, respectively. Bone pathology and metabolism were evaluated via immunohistochemical staining. The serum levels of alkaline phosphatase (ALP), tumor necrosis factor-alpha (TNF-α), tartrate-resistant acid phosphatase 5b (Tracp5b), and C-terminal telopeptide (CTx) were analyzed at 4 and 12 weeks post-operation. Removal of the spleen led to alterations in the homeostasis of bone metabolism and increased bone formation in rats. In this study, our findings indicate that the spleen is involved in skeletal metabolism. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

基金：
National Natural Sciences Foundation of China (31370987, 30901333 and 81371900) and GDHVPS (2011).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 3 区 医学
小类 | 2 区 骨科
最新[2025]版：
大类 | 3 区 医学
小类 | 4 区 骨科
JCR分区：
出版当年[2013]版：
Q1 ORTHOPEDICS
最新[2023]版：
Q2 ORTHOPEDICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Department of Orthopedics, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510665, China, [2]Department of Orthopedics & Microsurgery, Guangdong No. 2 Provincial People’s Hospital, Guangzhou 510317, China,
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510665, China, [4]Department of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China,
推荐引用方式(GB/T 7714)：
Sun Dawei,Zheng Xiaochen,Chen Yuhui,et al.Enhancement of osteogenesis post-splenectomy does not attenuate bone loss in ovariectomized rats.[J].JOURNAL OF ORTHOPAEDIC RESEARCH.2015,33(9):1356-1363.doi:10.1002/jor.22825.
APA：
Sun Dawei,Zheng Xiaochen,Chen Yuhui,Jia Chunhong,Xu Song...&Bai Xiaochun.(2015).Enhancement of osteogenesis post-splenectomy does not attenuate bone loss in ovariectomized rats..JOURNAL OF ORTHOPAEDIC RESEARCH,33,(9)
MLA：
Sun Dawei,et al."Enhancement of osteogenesis post-splenectomy does not attenuate bone loss in ovariectomized rats.".JOURNAL OF ORTHOPAEDIC RESEARCH 33..9(2015):1356-1363

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