机构：[1]Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China[2]School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China[3]Haizhu Maternal and Child Health Hospital, Guangzhou, People’s Republic of China[4]The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China[5]Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China
Salivary α-amylase (sAA) is responsible for the 'pre-digestion' of starch in the oral cavity and accounts for up to 50 % of salivary protein in human saliva. An accumulating body of literature suggests that sAA is of nutritional importance; however, it is still not clear how sAA is related to individual's nutritional status. Although copy number variations (CNV) of the salivary amylase gene (AMY1) are associated with variation in sAA levels, a significant amount of sAA variation is not explained by AMY1 CNV. To measure sAA responses to gustatory stimulation with citric acid, we used sAA ratio (the ratio of stimulated sAA levels to those of resting sAA) and investigated acute sAA responses to citric acid in children with normal (Normal-BMI, n 22) and low (Low-BMI, n 21) BMI. The AMY1 gene copy number was determined by quantitative PCR. We, for the first time, demonstrated attenuated acute sAA responses (decreased sAA ratio) to gustatory stimulation in Low-BMI (thinness grade 3) children compared with the Normal-BMI children, which suggest that sAA responses to gustatory stimulation may be of nutritional importance. However, child's nutritional status was not directly related to their resting or stimulated sAA levels, and it was not associated with AMY1 gene copy number. Finally, AMY1 CNV might influence, but did not eventually determine, sAA levels in children.
基金：
National Natural
Science Foundation of China (Z. M. Y., grant no. 81102703),
the Administration of Traditional Chinese Medicine of Guangdong
Province of China (Z. M. Y., grant no. 20123001), the
Science and Technology Planning Project of Guangdong
Province of China (Z. M. Y., grant no. 2013A032500005) and
the Special Funds from Central Finance of China in Support of
the Development of Local Colleges and Universities in 2013
(W. W. C., grant no. 338).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区医学
小类|3 区营养学
最新[2025]版：
大类|3 区医学
小类|3 区营养学
第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Long Hui,Yang Ze Min,Chen Wei Wen,et al.Attenuated acute salivary α-amylase responses to gustatory stimulation with citric acid in thin children.[J].The British journal of nutrition.2015,113(7):1078-85.doi:10.1017/S0007114515000446.
APA：
Chen Long Hui,Yang Ze Min,Chen Wei Wen,Lin Jing,Zhang Min...&Zhao Ling Bo.(2015).Attenuated acute salivary α-amylase responses to gustatory stimulation with citric acid in thin children..The British journal of nutrition,113,(7)
MLA：
Chen Long Hui,et al."Attenuated acute salivary α-amylase responses to gustatory stimulation with citric acid in thin children.".The British journal of nutrition 113..7(2015):1078-85
