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Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice.

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收录情况： ◇ SCIE

作者：
Liang Fengyin[1] * ; Luo Chuanming[2] * ; Xu Guangqing[3] ; Su Fengjuan[1] ; He Xiaofei[3] ; Long Simei[1] ; Ren Huixia[2] ; Liu Yaning[1] ; Feng Yanqing[1] ; Pei Zhong[1] ;
机构： [1]Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China [2]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China [3]Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
出处：
DOI： 10.1016/j.neulet.2015.05.006
ISSN：

关键词： Aquaporin-4 (AQP4) Micro traumatic brain injury Acute stage Cerebral edema

摘要：
Micro traumatic brain injury (TBI) is the most common type of brain injury, but the mechanisms underlying it are poorly understood. Aquaporin-4 (AQP4) is a water channel expressed in astrocyte end-feet, which plays an important role in brain edema. However, little is known about the role of AQP4 in micro TBI. Here, we examined the role of AQP4 in the pathogenesis of micro TBI in a closed-skull brain injury model, using two-photon microscopy. Our results indicate that AQP4 deletion reduced cell death, water content, astrocyte swelling and lesion volume during the acute stage of micro TBI. Our data revealed that astrocyte swelling is a decisive pathophysiological factor in the acute phase of this form of micro brain injury. Thus, treatments that inhibit AQP4 could be used as a neuroprotective strategy for micro TBI. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

基金：
National Key Clinical Department, National Key Discipline, Guangdong Key Laboratory For Diagnosis and Treatment of Major Neurological Diseases (No. 2010A060801005), Guangdong Science and technology project (No. 2013B051000018).
语种：
外文
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中科院(CAS)分区：
出版当年[2014]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
JCR分区：
出版当年[2013]版：
Q3 NEUROSCIENCES
最新[2023]版：
Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liang Fengyin,Luo Chuanming,Xu Guangqing,et al.Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice.[J].NEUROSCIENCE LETTERS.2015,598:29-35.doi:10.1016/j.neulet.2015.05.006.
APA：
Liang Fengyin,Luo Chuanming,Xu Guangqing,Su Fengjuan,He Xiaofei...&Pei Zhong.(2015).Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice..NEUROSCIENCE LETTERS,598,
MLA：
Liang Fengyin,et al."Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice.".NEUROSCIENCE LETTERS 598.(2015):29-35

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