机构：[1]National Key Disciplines, Department of Forensic and Pathology, Shantou University Medical College, 515041 Shantou, Guangdong Province, People’s Republic of China[2]Department of Forensic and Pathology, Jiaxing University Medical College, 314001 Jiaxing, Zhejiang Province, People’s Republic of China[3]Department of Forensic Pathology, Jiaxing Zhiyuan Forensic Science Institute, 314001 Jiaxing, Zhejiang Province, People’s Republic of China[4]Department of PreventiveMedicine, School of Public Health, Beihua University, 132013 Jilin, Jilin Province, People’s Republic of China[5]Department of Pathology, Jiaxing Hospital of Traditional Chinese Medicine, 314001 Jiaxing, Zhejiang Province, People’s Republic of China
Proper trace element level is crucial for the organs in maintaining normal physiological functions. Multiple organ failure (MOF) might be added to critically ill patients due to a lack of trace elements. Alterations of trace element levels in brain, heart, liver, and kidney after severe trauma, however, have been little studied so far. In this study, tissue samples of the frontal cortex of the brain, interventricular septum of the heart, right lobe of the liver, and upper pole of the kidney were obtained from forensic autopsies, of which 120 cases died during the 5th to 15th day of hospitalization, whereas the trauma death group and 43 cases immediately died due to severe craniocerebral trauma as the control group. Copper (Cu), iron (Fe), zinc (Zn), and selenium (Se) were quantified by inductively coupled plasma atomic emission spectrophotometry (ICP-AES). Cu, Fe, Zn, and Se concentrations in the brain, heart, liver, and kidney in the trauma group decreased dramatically (p<0.05) compared to the control group. The incidence of secondary infection and multiple organ failure (MOF) in the trauma death group were 78.33 and 29.17%, respectively. The concentrations of all elements exhibited a significant correlation with secondary infection and MOF (p<0.01). Our data suggest that low concentrations of Cu, Fe, Zn, and Se in pivotal organs may contribute to the incidence of secondary infection and MOF after severe trauma, which to some extent results in death.
基金：
The authors thank Long Xu (Laboratory of Environmental
Medicine and Developmental Toxicology, SUMC) for critical
reading of the manuscript. We appreciate the support from the Zhejiang
Provincial Natural Science Foundation (LQ14H230001), Scientific Research
Fund of Zhejiang Provincial Education Department
(Y201330031), and the National Natural Science Foundation Council
of China (30772458, 81400489, and 81400654).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区生物
小类|4 区生化与分子生物学4 区内分泌学与代谢
最新[2025]版：
大类|3 区生物学
小类|3 区生化与分子生物学4 区内分泌学与代谢
第一作者：
第一作者机构：[1]National Key Disciplines, Department of Forensic and Pathology, Shantou University Medical College, 515041 Shantou, Guangdong Province, People’s Republic of China[2]Department of Forensic and Pathology, Jiaxing University Medical College, 314001 Jiaxing, Zhejiang Province, People’s Republic of China[3]Department of Forensic Pathology, Jiaxing Zhiyuan Forensic Science Institute, 314001 Jiaxing, Zhejiang Province, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]National Key Disciplines, Department of Forensic and Pathology, Shantou University Medical College, 515041 Shantou, Guangdong Province, People’s Republic of China[2]Department of Forensic and Pathology, Jiaxing University Medical College, 314001 Jiaxing, Zhejiang Province, People’s Republic of China[3]Department of Forensic Pathology, Jiaxing Zhiyuan Forensic Science Institute, 314001 Jiaxing, Zhejiang Province, People’s Republic of China
推荐引用方式(GB/T 7714)：
Guangtao Xu,Ruibing Su,Bo Li,et al.Trace Element Concentrations in Human Tissues of Death Cases Associated With Secondary Infection and MOF After Severe Trauma.[J].Biological trace element research.2015,168(2):335-9.doi:10.1007/s12011-015-0378-4.
APA：
Guangtao Xu,Ruibing Su,Bo Li,Junyao Lv,Weiqi Sun...&Xiaojun Yu.(2015).Trace Element Concentrations in Human Tissues of Death Cases Associated With Secondary Infection and MOF After Severe Trauma..Biological trace element research,168,(2)
MLA：
Guangtao Xu,et al."Trace Element Concentrations in Human Tissues of Death Cases Associated With Secondary Infection and MOF After Severe Trauma.".Biological trace element research 168..2(2015):335-9
