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Quality assessment of crude and processed ginger by high-performance liquid chromatography with diode array detection and mass spectrometry combined with chemometrics.

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机构： [1]Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China [2]Division of Traditional Chinese Medicines Standard, Chinese Pharmacopoeia Commission, Beijing, China [3]Department of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA [4]Zhongshan Torch Polytechnic, Zhongshan, Guangdong, China [5]Guangzhou Medical University Cancer Hospital and Institute, Guangzhou, Guangdong, China

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关键词： Chemometrics / Ginger / High-performance liquid chromatography /Mass spectrometry / Quality assessment

摘要：

A sensitive, simple, and validated high-performance liquid chromatography with diode array detection and mass spectrometry detection method was developed for three ginger-based traditional Chinese herbal drugs, Zingiberis Rhizoma, Zingiberis Rhizome Preparatum, and Zingiberis Rhizome Carbonisata. Chemometrics methods, such as principal component analysis, hierarchical cluster analysis, and analysis of variance, were also employed in the data analysis. The results clearly revealed significant differences among Zingiberis Rhizoma, Zingiberis Rhizome Preparatum, and Zingiberis Rhizome Carbonisata, indicating variations in their chemical compositions during the processing, which may elucidate the relationship of the thermal treatment with the change of the constituents and interpret their different clinical uses. Furthermore, the sample consistency of Zingiberis Rhizoma, Zingiberis Rhizome Preparatum, and Zingiberis Rhizome Carbonisata can also be visualized by high-performance liquid chromatography with diode array detection and mass spectrometry analysis followed by principal component analysis/hierarchical cluster analysis. The comprehensive strategy of liquid chromatography with mass spectrometry analysis coupled with chemometrics should be useful in quality assurance for ginger-based herbal drugs and other herbal medicines. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2014]版：

大类 | 3 区化学

小类 | 3 区分析化学

最新[2025]版：

大类 | 3 区工程技术

小类 | 3 区分析化学

第一作者：

第一作者机构： [1]Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China

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通讯作者：

通讯机构： [1]Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China [3]Department of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA [*1]Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China

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Quality assessment of crude and processed ginger by high-performance liquid chromatography with diode array detection and mass spectrometry combined with chemometrics.

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