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Antinociceptive effect of intrathecal amiloride on neuropathic pain in rats.

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机构： [1]Department of Anesthesiology, Cancer Center, Sun Yat-Sen University, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, People’s Republic of China [2]Department of Gastrointestinal Surgery, 1st Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, People’s Republic of China

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关键词： Neuropathic pain Amiloride c-Fos p38 MAPK

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The aim of this study was to investigate the antinociception of intrathecal amiloride and examine its effect on the neuropathic pain-induced activation of c-Fos and p-p38 MAPK in the rat spinal dorsal horn (SDH). Sprague-Dawley rats were chronically implanted with intrathecal catheters, and the ability of intrathecal amiloride to alleviate nociceptive behaviours in rats with neuropathic pain was tested. Immunohistochemical techniques were utilized to detect the expression of c-Fos and p-p38 in SDH in the control and amiloride (100μg) groups. Intrathecal amiloride produced dose- and time-dependent antinociception in rats. Additionally, immunohistochemical experiments showed that the expression of c-Fos and p-p38 dramatically decreased in the superficial laminae of the ipsilateral SDH in the 100-μg amiloride group (P<0.01), whereas, there was no statistical significance on the contralateral side, compared with the control group. Intrathecally administered amiloride develops dose- and time-dependent antinociceptive action in rats with neuropathic pain. It most likely reduces spinal neurons and microglia activation via inhibiting c-Fos and p-p38 MAPK in the SDH of rats. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2013]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.5 最新[2023版] 2.5 最新五年平均 2.055 出版当年[2013版] 2.201 出版当年五年平均 2.026 出版前一年[2012版] 2.03 出版后一年[2014版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, Cancer Center, Sun Yat-Sen University, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, People’s Republic of China

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