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Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes.

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Ming[1] * ; Xiu Liangchang[2] ; Diao Jianxin[3] ; Wei Lianbo[1] ; Sun Jia[4] ;
机构： [1]Nephrology center of integrated traditional Chinese Medicine and Western Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, 510280, China [2]Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College, Dongguan, Guangdong 523808, China [3]The key laboratory of molecular biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China [4]Department of Endocrinology, Zhu/iang Hospital, Southern Medical University, Guangzhou ,510280 China
出处：
DOI： 10.1016/j.ejphar.2015.10.050
ISSN：

关键词： Sparstolonin B LPS NF-κB TLR4 3T3-L1 adipocyte

摘要：
Sparstolonin B (SsnB), an isocoumarin compound isolated from the tubers of both Sparganium stoloniferum and Scirpus yagara, has been reported to have anti-inflammatory effects. However, whether SsnB has anti-inflammatory effects on LPS-stimulated 3T3-L1 adipocytes remains unclear. In this study, we investigated the effects of SsnB on adipocyte inflammation in 3T3-L1 adipocytes and anti-obesity properties in high fat diet (HFD)-induced obese rats. 3T3-L1 adipocytes were pretreated with SsnB 1h before LPS treatment. The expression of MCP-1, IL-6, TNF-α, and IL-10 were measured by qRT-PCR and ELISA. The expression of PPAR-γ, TLR4 and NF-κB were detected by western blotting. SsnB was administered to HFD-induced obese rats to confirm its effects in vivo. Our results showed that SsnB dose-dependently inhibited LPS-induced MCP-1, IL-6, and TNF-α production. SsnB was found to inhibit LPS-induced TLR4 expression and NF-κB activition. Furthermore, SsnB was found to activate PPAR-γ and the inhibitory effects of SsnB on MCP-1, IL-6, and TNF-α production can be reversed by PPAR-γ antagonist GW9662. In vivo, SsnB was found to reduce the body weight of rats fed with HFD. SsnB also inhibited the levels of serum triglyceride (TG) and cholesterol (TC) induced by HFD. In conclusion, the results suggested that SsnB could reduce HFD-induced obesity in rats and inhibited LPS-induced cytokines production in 3T3-L1 adipocytes by activating PPAR-γ. Copyright © 2015 Elsevier B.V. All rights reserved.

基金：
work was supported by the National Natural Science Foundation of China (No. 81300689, No. 81403215), PhD. Programs Foundation of the Ministry of Education of China's Guangdong province (No. 20134433120005), Seedling Projects of Science China's Guangdong province (2013LYM_0008), Outstanding Young Teachers Development Foundation of Southern Medical University
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 3 区 医学
小类 | 3 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 药学
JCR分区：
出版当年[2013]版：
Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Nephrology center of integrated traditional Chinese Medicine and Western Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, 510280, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Ming,Xiu Liangchang,Diao Jianxin,et al.Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes.[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2015,769:79-85.doi:10.1016/j.ejphar.2015.10.050.
APA：
Wang Ming,Xiu Liangchang,Diao Jianxin,Wei Lianbo&Sun Jia.(2015).Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes..EUROPEAN JOURNAL OF PHARMACOLOGY,769,
MLA：
Wang Ming,et al."Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes.".EUROPEAN JOURNAL OF PHARMACOLOGY 769.(2015):79-85

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