机构：[1]Xinyuan Institute of Medicine and Biotechnology, College of Biological Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China[2]Research Institute of Traditional Chinese Medicine, Guangdong Medical College, 2 # Wenmingdong Road, Xiashan, Zhanjiang 524023, China[3]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College, Dongguan 523808, China[4]Department of Pathology, Taiping People’s Hospital of Dongguan, Dongguan Hospital Affiliated to Medical College of Jinan University, Dongguan 523905, China
Mixed adenoneuroendocrine carcinoma (MANEC) is exceedingly rare with a poor outcome. In this article, we reported a MANEC in a 68-year-old woman with a symptom of abdominal pain and distension. MANEC derived from the ascending colon with highly aggressive behavior. The diagnosis and distinguish of MANEC must base on histological findings and immunohistochemical findings. In this case, microscopic observation showed tumor cells were arranged in conglobate and nested by fibrous tissue with a visible cell atypia and mitotic. NEC-like and exocrine glandular cells were also been seen in a single neoplasm. MANEC tissues were immunopositive for CK, CK20, P53, CK7, CDX-2, Ki-67 (70%+), E-cad, CD56, CEA, Syn, villin and CgA, and immunonegative for CA125, NSE, ER and PR. Here, the patient was treated by surgical operation and was followed-up near 3 months, no local recurrence and distant metastasis.
基金：
Science and Technology Project of Dongguan (2013105-1010006) and the Science and Technology
Fund of Guangdong Medical College (XK1454).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|3 区病理学4 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
第一作者：
第一作者机构：[1]Xinyuan Institute of Medicine and Biotechnology, College of Biological Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China
共同第一作者：
通讯作者：
通讯机构：[4]Department of Pathology, Taiping People’s Hospital of Dongguan, Dongguan Hospital Affiliated to Medical College of Jinan University, Dongguan 523905, China[*1]Department of Pathology, Taiping People’s Hospital of Dongguan, Dongguan Hospital Affiliated to Medical College of Jinan University, Dongguan 523905, China
推荐引用方式(GB/T 7714)：
Liu Xi-Jun,Feng Jin-Shan,Xiang Wen-Yu,et al.Clinicopathological features of an ascending colon mixed adenoneuroendocrine carcinoma with clinical serosal invasion.[J].International journal of clinical and experimental pathology.2014,7(9):6395-8.
APA：
Liu Xi-Jun,Feng Jin-Shan,Xiang Wen-Yu,Kong Bin,Wang Ling-Mei...&Liang Yan-Fang.(2014).Clinicopathological features of an ascending colon mixed adenoneuroendocrine carcinoma with clinical serosal invasion..International journal of clinical and experimental pathology,7,(9)
MLA：
Liu Xi-Jun,et al."Clinicopathological features of an ascending colon mixed adenoneuroendocrine carcinoma with clinical serosal invasion.".International journal of clinical and experimental pathology 7..9(2014):6395-8
