机构：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hong Kong, Guangzhou 510632, Guangdong Province, China[4]Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[5]STD/AIDS Research Lab, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca(2+) overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage.
基金：
This work was supported by the National Natural
Science Foundation of China, No. 81171134; Major State Basic
Research Development Program (973 Program), No.
2011CB707500; Science and Technology Foundation of
Guangzhou, No. 2010Y1-C291; Science and Technology
Foundation of Guangdong Province, No. 2010B030700017;
Guangdong Medical Research Funds, No. B2010160; Jinan
University-National College Students’ Innovative
Entrepreneurial Training Programs in 2012, No. 1210559039;
the Key Laboratory’s Open Fund of Jinan University, No.
51212003; College Students’ Extracurricular Scientific
Innovation and Entrepreneurial Activity Research Topic of Jinan
University Challenge Cup in 2012, No. (2012) 42.
第一作者机构：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hong Kong, Guangzhou 510632, Guangdong Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hong Kong, Guangzhou 510632, Guangdong Province, China[*1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[*2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[*3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hong Kong, Guangzhou 510632, Guangdong Province, China,
推荐引用方式(GB/T 7714)：
Hongmei Tang,Rui Pan,Wenli Fang,et al.Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1.[J].NEURAL REGENERATION RESEARCH.2013,8(15):1368-1375.doi:10.3969/j.issn.1673-5374.2013.15.003.
APA：
Hongmei Tang,Rui Pan,Wenli Fang,Yanyan Xing,Dexi Chen...&Jun Dong.(2013).Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1..NEURAL REGENERATION RESEARCH,8,(15)
MLA：
Hongmei Tang,et al."Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1.".NEURAL REGENERATION RESEARCH 8..15(2013):1368-1375
