机构：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China[4]Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China
Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
基金：
Natural Science Foundation of Guangdong Province, No. 9151040701000,
061050246; the Science and Technology Project of Guangdong
Province, No. 2010B030700016; the Science and Technology
Project of Guangzhou, No. 2010Y1-C291; the National Natural
Science Foundation of China, No. 81171134.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2011]版：
大类|4 区医学
小类|4 区细胞生物学4 区神经科学
最新[2025]版：
大类|2 区医学
小类|2 区细胞生物学2 区神经科学
第一作者：
第一作者机构：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China[*1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[*2]Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China[*3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China
推荐引用方式(GB/T 7714)：
Gong Zheng,Yang Lijuan,Tang Hongmei,et al.Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats.[J].Neural Regeneration Research.2012,7(3):171-5.doi:10.3969/j.issn.1673-5374.2012.03.002.
APA：
Gong Zheng,Yang Lijuan,Tang Hongmei,Pan Rui,Xie Sai...&Dong Jun.(2012).Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats..Neural Regeneration Research,7,(3)
MLA：
Gong Zheng,et al."Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats.".Neural Regeneration Research 7..3(2012):171-5
