机构：[1]Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[2]Department of Hepatology, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China[3]Department of Infectious Diseases, China-Japan Friendship Hospital, Beijing, China[4]Department of Infectious Diseases, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, China[5]Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China[6]Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China中山大学附属第三医院[7]Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China四川大学华西医院[8]Shanghai Liver Diseases Research Center, 85th Hospital, Nanjing Military Command, Shanghai, China[9]Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[10]Department of Infectious Diseases, First Affiliated Hospital of the Army Medical University, Chongqing, China[11]Department of Hepatology, First Hospital of Jilin University, Changchun, Jilin Province, China[12]Tianjin Key Laboratory of Artificial Cells, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin Third Central Hospital, Tianjin,China[13]Department of Infectious Diseases, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China江苏省人民医院[14]Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China[15]Center of Liver Diseases, General Hospital of Beijing Military Region, Beijing, China[16]Clinical Epidemiology and Evidence-Based Medical Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[17]Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[18]Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing, China[19]Department of Pathology, China-Japan Friendship Hospital, Beijing, China
To validate the operational and diagnostic performance of a new device of transient elastography (FibroTouch) for liver fibrosis in patients with chronic hepatitis B (CHB).
In this prospective multicenter study, adult patients with CHB and valid liver pathological results were recruited to validate the operational and diagnostic performance of transient elastography (TE) by FibroTouch for staging liver fibrosis.
Totally, 517 patients with histologically proven CHB were enrolled. All of them had successful liver stiffness measurement (LSM) more than 10 times, resulting in a success rate of 99.5% and reliable evaluations of 95.2%. Four hundred and twelve patients were included for analysis of diagnostic performance. The Area Under the Receiver Operating Characteristics (AUROCs) for LSM were 0.846 (95% confidence interval [CI],0.808-0.880) for ≥F1, 0.850(95% CI,0.811-0.883) for ≥ F2, 0.908 (95% CI, 0.871-0.942) for ≥ F3 and 0.874(95%CI, 0.836-0.903) for F4. The diagnostic accuracy of LSM was better than that of GPR, APRI, or FIB-4 in staging fibrosis F1-F4 (p = 0.007 to p < 0.0001). Optimal LSM cut-off values for diagnosing fibrosis stage ≥ F1, ≥ F2, ≥ F3, and F4 were 5.5 kPa, 7.85 kPa, 10.0 kPa, and 12.7 kPa, respectively.
TE (FibroTouch) has a high success rate and good reliability in staging liver fibrosis in patients with CHB. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
第一作者机构：[1]Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosi, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Duan Weijia,Wang Xiaozhong,Ma Anlin,et al.A multicenter prospective study to validate a new device of transient elastography for staging liver fibrosis in patients with chronic hepatitis B.[J].JOURNAL OF DIGESTIVE DISEASES.2020,21(9):519-525.doi:10.1111/1751-2980.12924.
APA：
Duan Weijia,Wang Xiaozhong,Ma Anlin,Shang Jia,Nan Yuemin...&Jia Jidong.(2020).A multicenter prospective study to validate a new device of transient elastography for staging liver fibrosis in patients with chronic hepatitis B..JOURNAL OF DIGESTIVE DISEASES,21,(9)
MLA：
Duan Weijia,et al."A multicenter prospective study to validate a new device of transient elastography for staging liver fibrosis in patients with chronic hepatitis B.".JOURNAL OF DIGESTIVE DISEASES 21..9(2020):519-525
