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In vivo odorant input induces distinct synaptic plasticity of GABAergic synapses in developing zebrafish olfactory bulb.

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收录情况： ◇ SCIE

作者：
Hu Bin[1,3] * ; Jin Chen[1] ; Zhang Yi-Qian[4] ; Miao Hao-Ran[4] ; Wang Feng[2] ;
机构： [1]Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China [2]Neurology Department, Seventh People’s Hospital of Shanghai, University of Traditional Chinese Medicine, Shanghai, 200137, China [3]Department of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, 211166, China [4]Department of Thoracic Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518033, China
出处：
DOI： 10.1016/j.bbrc.2020.07.106
ISSN：

关键词： Spike timing-dependent plasticity GABAergic Recurrent inhibition Lateral inhibition Olfactory bulb NMDAR

摘要：
In the first station of central odor processing, the main olfactory bulb, signal processing is regulated by synaptic interactions between glutamatergic and GABAergic inputs of the mitral cells (MCs), the major projection neurons. Our previous study has found that repetitive postsynaptic spiking within a critical time window after presynaptic activation by natural odorant stimulation results in persistent enhancement of glutamatergic inputs of MCs in larval zebrafish. Here we observed a long-term depression of GABAergic synapses induced by the same protocol. This long-term depression was mediated by presynaptic NMDA receptors (NMDARs). Further dissecting GABAergic neurotransmission revealed that the STDP-induction protocol induced persistent modification in recurrent and lateral inhibition with opposite directions and distinct requirements on NMDARs. Thus, at the plasticity level, different types of GABAergic inhibition may utilize different mechanisms to cooperate or compete with excitatory inputs to optimize patterns of olfactory bulb output. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
This work was supported by grants from National Natural Science Foundation of China [81701084], the Natural Science Foundation of Shanghai [18ZR14307000], and the Natural Science Foundation of the Jiangsu Higher Education Institutions [17KJB320020].
语种：
外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 生物
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
JCR分区：
出版当年[2018]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China [3]Department of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, 211166, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Bin,Jin Chen,Zhang Yi-Qian,et al.In vivo odorant input induces distinct synaptic plasticity of GABAergic synapses in developing zebrafish olfactory bulb.[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2020,531(2):160-165.doi:10.1016/j.bbrc.2020.07.106.
APA：
Hu Bin,Jin Chen,Zhang Yi-Qian,Miao Hao-Ran&Wang Feng.(2020).In vivo odorant input induces distinct synaptic plasticity of GABAergic synapses in developing zebrafish olfactory bulb..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,531,(2)
MLA：
Hu Bin,et al."In vivo odorant input induces distinct synaptic plasticity of GABAergic synapses in developing zebrafish olfactory bulb.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 531..2(2020):160-165

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