机构：[1]Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, PR China[2]Department of Gynecology of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, PR China
Aim: To construct a survival prediction signature for prostate cancer (PC) based on the RNA N6-methyladenosine (m6A) methylation regulator. Materials & methods: This paper explores the interaction network of differentially expressed m6A RNA methylation regulators in PC by Pearson correlation analysis. Univariate Cox risk regression and LASSO regression analysis were used to construct a predictive signature of PC. Kaplan-Meier survival analysis compared the overall survival of the high- and low-risk groups. Results & Conclusion: We first constructed a prognostic two gene signature for PC based on the m6A RNA methylation regulators MRTTL14 and YTHDF2. The interaction network of m6A RNA methylation regulators in PC was also established.
基金：
This work was supported by the grants from Science and technology innovation project for college students of Guangzhou Medical
University (no. 2019A003 for J Wang). This work was supported by the grants from National Natural Science Foundation of
China (nos. 81372774, 81572537 for Z Zhao), The Key Program of Natural Science Foundation of Guangdong Province (no.
2015A030311007 for Z Zhao), Science and Technology Program of Guangzhou (no. 201607010376 for Z Zhao) and The Major
Program of Department of Guangdong Education (no. 2017KZDXM067 for Z Zhao).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Jiamin,Lin Han,Zhou Mingda,et al.The m6A methylation regulator-based signature for predicting the prognosis of prostate cancer.[J].Future oncology (London, England).2020,16(30):2421-2432.doi:10.2217/fon-2020-0330.
APA：
Wang Jiamin,Lin Han,Zhou Mingda,Xiang Qian,Deng Yihan...&Zhao Zhigang.(2020).The m6A methylation regulator-based signature for predicting the prognosis of prostate cancer..Future oncology (London, England),16,(30)
MLA：
Wang Jiamin,et al."The m6A methylation regulator-based signature for predicting the prognosis of prostate cancer.".Future oncology (London, England) 16..30(2020):2421-2432
