机构：[1]Department of Cardiology, The Third Hospital of Changsha, Changsha, Hunan, China[2]Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, China[3]Central Laboratory, Fengxian Hospital Affiliated to the Southern Medical University, Shanghai, China[4]Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, Shanghai, China[5]The Third School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China[6]Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD). Platelet P-selectin (CD62P) is a classic platelet activation indicator on the platelet surface, and soluble TREM-like transcript-1 (sTLT-1) is a new indicator. However, the relationship between these two markers and CAD, especially in acute coronary syndrome (ACS), has not been elucidated. This study aimed to investigate CD62P expression on the platelet surface and sTLT-1 expression in serum, as well as to assess their relationship with CAD.
We measured the levels of CD62P and sTLT-1 in 83 patients with CAD compared to 49 controls. The association of these indicators with age, blood pressure, lipid profile, body mass index, and liver injury marker level were also examined.
CD62P concentration was higher in CAD patients than in the control group (P < 0.01), especially in acute myocardial infarction (AMI) patients (P < 0.01). Serum sTLT-1 concentration was higher in the AMI and unstable angina pectoris (UAP) groups than in the normal control (NC) group (P < 0.01).
The consistency of sTLT-1 and CD62P expression levels in CAD patients indicates that sTLT-1 level, the same as CD62P, may be a new marker of platelet activation that is positively related to CAD.
基金：
National Nature Science Foundation of China (grant number 31570949)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区心脏和心血管系统
最新[2025]版：
大类|3 区医学
小类|4 区心脏和心血管系统
第一作者：
第一作者机构：[1]Department of Cardiology, The Third Hospital of Changsha, Changsha, Hunan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shen Li,Yang Tianlun,Xia Ke,et al.P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study.[J].BMC cardiovascular disorders.2020,20(1):387.doi:10.1186/s12872-020-01663-2.
APA：
Shen Li,Yang Tianlun,Xia Ke,Yan Zhiqiang,Tan Juanjuan...&Shi Wei.(2020).P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study..BMC cardiovascular disorders,20,(1)
MLA：
Shen Li,et al."P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study.".BMC cardiovascular disorders 20..1(2020):387
