机构：[1]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, No.12 Airport Road, Baiyun District, Guangzhou 510407, China深圳市中医院深圳医学信息中心[2]Department ofLaboratory Medicine, Guangdong Second Provincial General Hospital, No.466 Xingang Middle Road, Haizhu District, Guangzhou 510317, GuangdongProvince, China[3]Lingnan Medical Research Center, Guangzhou University ofChinese Medicine, Guangzhou 510407, China深圳市中医院深圳医学信息中心
Sphingosine-1-phosphate receptor (S1PR1) is involved in vascular development, a key process in tumorigenesis. This study aimed to evaluate its roles in tumor development and prognosis.
S1PR1 expression levels were analyzed using TIMER and Oncomine database, and the prognostic significance of S1PR1 was assessed using PrognoScan and Kaplan-Meier plotter databases. The relationship between S1PR1 and tumor-infiltrated immune cells was analyzed using TIMER.
S1PR1 expression was remarkably lower in breast and lung cancer tissues than in the corresponding normal tissues. Lower expression was related to poor overall survival and disease-free survival in breast invasive carcinoma (BRCA), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC). A functional network analysis confirmed the function of S1PR1 in regulating vasculogenesis. In addition, S1PR1 levels were significantly negative with regard to the tumor purity of BRCA (r = - 0.508, P = 1.76e-66), LUAD (r = - 0.353, P = 6.05e-16), and LUSC (r = - 0.402, P = - 5.20e-20). Furthermore, S1PR1 levels were significantly positive with regard to infiltrating CD8+ (r = 0.38, P = 5.91e-35) and CD4+ T cells (r = 0.335, P = 1.03e-26), macrophages (r = 0.219, P = 3.67e-12), neutrophils (r = 0.168, P = 2.03e-7), and dendritic cells (DCs) (r = 0.208, P = 9.14e-11) in BRCA; S1PR1 levels were significantly positive with regard to CD8+ T cells (r = 0.308, P = 3.61e-12), macrophages (r = 0.376, P = 1.01e-17), neutrophils (r = 0.246, P = 4.15e-8), and DCs (r = 0.207, P = 4.16e-6) in LUAD; and positive with regard to B cells (r = 0.356, P = 1.57e-15), CD8+ (r = 0.459, P = 3.83e-26) and CD4+ T cells (r = 0.338, P = 3.98e-14), macrophages (r = 0.566, P = 2.61e-45), neutrophils (r = 0.453, P = 1.79e-25), and DCs (r = 0.56, P = 2.12e-40) in LUSC.
S1PR1 levels are positively correlated with multiple immune markers in breast and lung cancer. These observed correlations between S1PR1 and the prognosis and immune cell infiltration provide a foundation for further research on its immunomodulatory role in cancer.
基金：
National Natural Science Foundation of China (No.
81700512), and Natural Science Foundation of Guangdong Province of China
(No. 2016A030310252).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, No.12 Airport Road, Baiyun District, Guangzhou 510407, China
通讯作者：
通讯机构：[2]Department ofLaboratory Medicine, Guangdong Second Provincial General Hospital, No.466 Xingang Middle Road, Haizhu District, Guangzhou 510317, GuangdongProvince, China[3]Lingnan Medical Research Center, Guangzhou University ofChinese Medicine, Guangzhou 510407, China
推荐引用方式(GB/T 7714)：
Zhong Limei,Xie Linling,Yang Zhiyong,et al.Prognostic value of S1PR1 and its correlation with immune infiltrates in breast and lung cancers.[J].BMC cancer.2020,20(1):766.doi:10.1186/s12885-020-07278-2.
APA：
Zhong Limei,Xie Linling,Yang Zhiyong,Li Lijuan,Song Shaohua...&Liu Yufeng.(2020).Prognostic value of S1PR1 and its correlation with immune infiltrates in breast and lung cancers..BMC cancer,20,(1)
MLA：
Zhong Limei,et al."Prognostic value of S1PR1 and its correlation with immune infiltrates in breast and lung cancers.".BMC cancer 20..1(2020):766
