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Immunomodulatory mechanism of a purified polysaccharide isolated from Isaria cicadae Miquel on RAW264.7 cells via activating TLR4-MAPK-NF-κB signaling pathway.

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机构： [1]School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]Emergency Center, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223001, Jiangsu, PR China [3]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou 510006, PR China [4]The Fourth Clinical Medicine College, Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, PR China [5]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai 264199, Shandong, PR China

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关键词： Polysaccharide from Isaria cicadae Miquel Immunomodulatory mechanism TLR4-MAPK-NF-KB signaling pathway

摘要：

The immunomodulatory effect of a novel purified polysaccharide (JCH-1) isolated from Isaria cicadae Miquel had been confirmed to promote secretion of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) in our previous study. However, the immunomodulatory mechanism was still unclear. The purpose of this study was to investigate the immunomodulatory mechanism of JCH-1. Experimental data showed that JCH-1 could increase protein expression of toll-like receptor 4 (TLR4), promote the phosphorylation of mitogen-activated protein kinase (MAPK), as well as nuclear factor-kappa B (NF-κB) p65. Importantly, TLR4 inhibitor inhibited JCH-1-induced activation of MAPK-NF-κB signaling pathway, thus suppressed JCH-1-induced secretion of NO, TNF-α and IL-6. Collectively, these results indicated that JCH-1 actives RAW264.7 cells through TLR4-MAPK-NF-κB signaling pathway. Copyright © 2018. Published by Elsevier B.V.

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出版当年[2019]版：

大类 | 2 区化学

小类 | 2 区应用化学 2 区高分子科学 3 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

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出版当年[2018]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 POLYMER SCIENCE Q1 CHEMISTRY, APPLIED

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 7.7 最新[2023版] 7.7 最新五年平均 4.784 出版当年[2018版] 4.731 出版当年五年平均 3.909 出版前一年[2017版] 5.162 出版后一年[2019版]

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第一作者机构： [1]School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China

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Immunomodulatory mechanism of a purified polysaccharide isolated from Isaria cicadae Miquel on RAW264.7 cells via activating TLR4-MAPK-NF-κB signaling pathway.

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