机构：[1]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.[2]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.[3]Shanxi Provincial Hospital of Chinese Medicine, Taiyuan, Shanxi, China.[4]Shandong University Reproductive Hospital, Jinan, Shandong, China.[5]Sun Yat-sen Memorial Hospital of the Sun Yat-sen University, Guangzhou, Guangdong, China.中山大学附属第二医院[6]Lanzhou University First Hospital, Lanzhou, Gansu, China.[7]Henan Provincial People’s Hospital, Zhengzhou, Henan, China.[8]Huazhong University of Science and Technology Reproductive Medicine Center of Tongji Medical College, Wuhan, Hubei, China.[9]Shanghai Shuguang Hospital, Shanghai, China.[10]East Region Military Command General Hospital, Nanjing, Jiangsu, China.[11]Luoyang Women and Children Health Care Center, Luoyang, Henan, China.
Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.
This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates, and high-quality embryo rates. The safety of acupuncture will also be assessed.
The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.
AMCTR-IPR-18000198 . Registered on 10 August 2018.
基金：
This study was supported by the National key research and development
program (NO. 2017YFC1703600) by the Ministry of Science and Technology
of the People’s Republic of China.
第一作者机构：[1]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huanfang Xu,Chensi Zheng,Liyun He,et al.Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial.[J].TRIALS.2020,21(1):doi:10.1186/s13063-020-04690-8.
APA：
Huanfang Xu,Chensi Zheng,Liyun He,Tongsheng Su,Huidan Wang...&Baoyan Liu.(2020).Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial..TRIALS,21,(1)
MLA：
Huanfang Xu,et al."Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial.".TRIALS 21..1(2020)
