个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Hui[1] * ; Zhu Fei-Yue[2] ; He Xiao-Juan[2] ; Tang Shi-Huan[1] ; Long Ting[1] ; Peng Lu[1] ; Zhang Hong-Mei[1] ; Zou Zong-Zhi[3] ; Xiong Zhu[4] ; Zhang Xian-Ping[1,*1] ;
机构： [1]Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China. [2]Department of Hematology, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China. [3]Department of Nephropathy Endocrinology, The Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, 410000, China. [4]Department of Pediatric Orthopedics, Shenzhen Children's Hospital of China Medical University, Guangdong, 518034, China.
出处：
DOI： 10.1515/biol-2022-0597
ISSN：

关键词： DNA fragmentation index reactive oxygen species apoptosis in vitro fertilization and embryo transfer/ intracytoplasmic sperm injection clinical pregnancy

摘要：
We investigated the influence of DNA fragmentation index (DFI) on in vitro fertilization (IVF), embryo transfer (ET), and intracytoplasmic sperm injection (ICSI). We analyzed the semen parameters of 61 cycles in infertile couples undergoing IVF-ET and ICSI and determined DFI by sperm chromatin dispersion testing. Based on DFI, the patients were differentiated into a control group (DFI < 25%, n = 35) and a test group (DFI ≥ 25%, n = 26). Flow cytometry and immunofluorescence were used to investigate the extent of sperm reactive oxygen species (ROS) and apoptosis. We also investigated the effect of DFI on pregnancy outcomes of IVF-ET/ICSI. DFI was negatively related to sperm motility and positively correlated with ROS and apoptosis (P < 0.05). Abnormally elevated DFI reduced the rate of transplantable, high-quality embryos, implantation, clinical pregnancy, delivery, and live birth after IVF-ET, and increased the chance of early abortion per transfer cycle (P < 0.05). However, there was no significant correlation between DFI and fertilization rate, cleavage rate, transplantable rate, high-quality embryo rate, implantation rate, clinical pregnancy rate, early abortion rate, delivery rate and live birth rate when assisted by ICSI (P > 0.05). Sperm DNA integrity is crucial for fertilization and the development of healthy offspring. ROS may increase the level of DFI by inducing apoptosis in sperm.© 2023 the author(s), published by De Gruyter.

基金：
This research was supported by the program for joint projects of the Natural Science Foundation of Hunan Province (Reference: 2021JJ70034), the Loudi Applied Technology Research and Development program (Reference: Loudi Finance Bureau teaching guidance 2020[43] document), the Sanming Project of Medicine in Shenzhen (Reference: SZSM202011012), the Shenzhen Fund for Guangdong Provincial High-level Clinical Key specialties (Reference: SZXK035), and the Shenzhen Innovation Science and Technology Committee (Reference: JCYJ20180228175358223).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 生物学
小类 | 4 区 生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生物学
JCR分区：
出版当年[2021]版：
Q4 BIOLOGY
最新[2023]版：
Q3 BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China.
通讯作者：
通讯机构： [1]Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China. [*1]Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
推荐引用方式(GB/T 7714)：
Zhang Hui,Zhu Fei-Yue,He Xiao-Juan,et al.The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology[J].OPEN LIFE SCIENCES.2023,18(1):doi:10.1515/biol-2022-0597.
APA：
Zhang Hui,Zhu Fei-Yue,He Xiao-Juan,Tang Shi-Huan,Long Ting...&Zhang Xian-Ping.(2023).The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology.OPEN LIFE SCIENCES,18,(1)
MLA：
Zhang Hui,et al."The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology".OPEN LIFE SCIENCES 18..1(2023)

相关文献

[1]Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells [2]Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells [3]Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells [4]Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells. [5]Reactive Oxygen Species Are Essential for Vasoconstriction upon Cold Exposure. [6]A novel RANKL-targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species. [7]Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species. [8]Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species. [9]Biomedical Application of Reactive Oxygen Species-Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases [10]A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer(Open Access)

资源点击量：2020 今日访问量：0 总访问量：646 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号