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A new organic heterocycles compound: Crystal structure and anti-cancer activity in skin cancer

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机构： [1]Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]Department of Dermatology, The 195 Hospital of Chinese People’s Liberation Army, Xianning, Hubei, China [3]Department of Dermatology, San Shui Branch Foshan Hospital of TCM, Foshan, Guangdong, China

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关键词： Heterocycles Skin cancer X-ray

摘要：

The new heterocycles compound N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1), designed using 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (2) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR,1H NMR, and single crystal X-ray crystallography. In addition, in vitro anticancer activity of compound 1 on three human skin cancer cell lines (A431, SK23 and HME1) was further determined. © 2018, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

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大类 | 4 区医学

小类 | 4 区药学

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第一作者机构： [1]Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

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