Classifier diversity and fusion architecture are two critical characteristics stressed in homogeneous and heterogeneous ensemble learning methods and they are equally important for building a successful multi-classifier system. In this study, we introduced a two-level framework, namely hierarchical fusion of homogeneous and heterogeneous multi-classifiers (HF2HM), to integrate the diversified classification models produced by feeding heterogeneous classifiers with homogeneous random-projected training datasets. The proposed hierarchical fusion scheme was comprehensively validated using fifteen public UCI datasets and three clinical datasets. The experimental results demonstrated the superiority of the proposed HF2HM framework over the base classifiers and the state-of-the-art benchmark ensemble methods, verifying it as a potential tool to assist in medical decision making in practical clinical settings. © 2020 Elsevier B.V.