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Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.

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文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ EI

作者：
Cui Yongsheng[1] * ; Zhu Lixia[2,5] * ; Li Yixuan[1,3] ; Jiang Siliang[1,3] ; Sun Qili[1,3] ; Xie Enyi[6] ; Chen Hubiao[2] ; Zhao Zhongzhen[2] ; Qiao Wei[1] ; Xu Jun[2,4,*1] ; Dong Caixia[1] ;
机构： [1]Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070,China [2]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong [3]Department of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China [4]Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing210028, China [5]The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518000, China [6]College of Fisheries, Guangdong Ocean University, Zhanjiang 524088, China
出处：
DOI： 10.1016/j.carbpol.2020.117389
ISSN：

关键词： Sargassum henslowianum β-(1→3)-Glucan In vitro fermentation Gut microbiota Short-chain fatty acids

摘要：
A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography. Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position. Thus, SHNP is a laminarin-type polysaccharide. In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased. Furthermore, SHNP regulated the intestinal microbiota composition by stimulating the growth of species belonging to Enterobacteriaceae while depleting Haemophilus parainfluenzae and Gemmiger formicilis. Taken together, these results indicate that SHNP has the potential for regulating gut microbiota, but its specific role in the regulation requires to be further investigated. Copyright © 2020 Elsevier Ltd. All rights reserved.

基金：
the National Natural Science Foundation of China (81803682 and 81872975), Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis (CTD2018-03), and Hong Kong General Research Fund (12100219 and 12103919)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 工程技术
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
最新[2025]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
JCR分区：
出版当年[2019]版：
Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE
最新[2023]版：
Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070,China
共同第一作者：
通讯作者：
通讯机构： [2]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong [4]Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing210028, China [*1]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
推荐引用方式(GB/T 7714)：
Cui Yongsheng,Zhu Lixia,Li Yixuan,et al.Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.[J].CARBOHYDRATE POLYMERS.2021,255:doi:10.1016/j.carbpol.2020.117389.
APA：
Cui Yongsheng,Zhu Lixia,Li Yixuan,Jiang Siliang,Sun Qili...&Dong Caixia.(2021).Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota..CARBOHYDRATE POLYMERS,255,
MLA：
Cui Yongsheng,et al."Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.".CARBOHYDRATE POLYMERS 255.(2021)

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