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Structural elucidation of three novel oligosaccharides from Kunlun Chrysanthemum flower tea and their bioactivities.

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资源类型：
Pubmed体系：
作者：
Yu Qian[1,2] * ; Chen Wei[1] * ; Zhong Jing[1] ; Qing Degang[3] ; Yan Chunyan[1,2] ;
机构： [1]Clinical pharmacy of the First Affiliated Hospital of Guangdong Pharmaceutical 8University,Guangzhou, 510060, China [2]School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China [3]Xinjiang Institute of Traditional Chinese Medicine and Ethnodrug, Urumqi, 830002, 12China
出处：
DOI： 10.1016/j.fct.2021.112032
ISSN：

关键词： Coreopsis tinctoria Kunlun Chrysanthemum oligosaccharides α-glucosidase inhibitory activity α-amylase inhibitory activity anti-neuroinflammation activity

摘要：
Coreopsis tinctoria is commonly called Kunlun Chrysanthemum and a plateau plant with tremendous commercial value in functional tea and medicinal applications. In folk medicine, Kunlun Chrysanthemum flower is often used as an adjunctive therapy for diabetes and Alzheimer's disease. To further explore the chemicals responsible for the health benefits of Kunlun Chrysanthemum flowers, three homogeneous oligosaccharides, CT70-1A, CT70-1B and CT70-2 were isolated, and their detailed structures were determined from chemical and spectral analyses. The three oligosaccharides were composed of glucose, mannose, galactose, and arabinose in different ratios. They showed dose-dependent α-amylase and α-glucosidase inhibitory effects. In addition, they showed NO production inhibitory activities in BV2 cells, with IC50 values of 0.23, 0.24 and 0.27 mM, respectively. Taken together, these results suggested that Kunlun Chrysanthemum oligosaccharides might ameliorate hyperglycemia and neuroinflammation, which could prevent the development of diseases such as type 2 diabetes and Alzheimer's disease. This study provides chemical and bioactive perspectives that support the consumption of Kunlun Chrysanthemum flower tea for health benefits. Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
the National Natural Science Foundation of China (Nos. U1703110, 81673557 and 81973454)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 1 区 食品科技 2 区 毒理学
最新[2025]版：
大类 | 4 区 医学
小类 | 3 区 食品科技 3 区 毒理学
第一作者：
第一作者机构： [1]Clinical pharmacy of the First Affiliated Hospital of Guangdong Pharmaceutical 8University,Guangzhou, 510060, China [2]School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China
共同第一作者：
通讯作者：
通讯机构： [1]Clinical pharmacy of the First Affiliated Hospital of Guangdong Pharmaceutical 8University,Guangzhou, 510060, China [2]School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China
推荐引用方式(GB/T 7714)：
Yu Qian,Chen Wei,Zhong Jing,et al.Structural elucidation of three novel oligosaccharides from Kunlun Chrysanthemum flower tea and their bioactivities.[J].Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.2021,149:112032.doi:10.1016/j.fct.2021.112032.
APA：
Yu Qian,Chen Wei,Zhong Jing,Qing Degang&Yan Chunyan.(2021).Structural elucidation of three novel oligosaccharides from Kunlun Chrysanthemum flower tea and their bioactivities..Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,149,
MLA：
Yu Qian,et al."Structural elucidation of three novel oligosaccharides from Kunlun Chrysanthemum flower tea and their bioactivities.".Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 149.(2021):112032

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