机构：[1]Zhujiang Hospital of Southern Medical University, Guangzhou, China[2]Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China[3]Second School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院
Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases.
Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases.
Keywords: glia maturation factor-β, neurodegeneration, neuroinflammation
第一作者机构：[1]Zhujiang Hospital of Southern Medical University, Guangzhou, China[2]Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Zhujiang Hospital of Southern Medical University, Guangzhou, China[*1]Zhujiang Hospital of Southern Medical University, 253 Industry Road, Guangzhou, Guangdong 510280, China
推荐引用方式(GB/T 7714)：
Fan Junsheng,Fong Tszhei,Chen Xinjie,et al.Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation.[J].NEUROPSYCHIATRIC DISEASE AND TREATMENT.2018,14:495-504.doi:10.2147/NDT.S157099.
APA：
Fan Junsheng,Fong Tszhei,Chen Xinjie,Chen Chuyun,Luo Peng&Xie Haiting.(2018).Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation..NEUROPSYCHIATRIC DISEASE AND TREATMENT,14,
MLA：
Fan Junsheng,et al."Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation.".NEUROPSYCHIATRIC DISEASE AND TREATMENT 14.(2018):495-504
