详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Emerging Perspectives of RNA N6-methyladenosine (m6A) Modification on Immunity and Autoimmune Diseases

15| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Pharmacology of Traditional Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China, [2]Department of Pathogen Biology, The Chinses Center for Disease Control and Prevention, Beijing, China, [3]Department of Pharmacy, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China, [4]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China, [5]Section of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China, [6]Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, [7]Department of Pathology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China

出处：

DOI：

ISSN：

关键词： N6-methyladenosine (m6A) innate immunity adaptive immunity autoimmune disease viral infection

摘要：

N6-methyladenosine (m6A) modification, the addition of a methylation decoration at the position of N6 of adenosine, is one of the most prevalent modifications among the over 100 known chemical modifications of RNA. Numerous studies have recently characterized that RNA m6A modification functions as a critical post-transcriptional regulator of gene expression through modulating various aspects of RNA metabolism. In this review, we will illustrate the current perspectives on the biological process of m6A methylation. Then we will further summarize the vital modulatory effects of m6A modification on immunity, viral infection, and autoinflammatory disorders. Recent studies suggest that m6A decoration plays an important role in immunity, viral infection, and autoimmune diseases, thereby providing promising biomarkers and therapeutic targets for viral infection and autoimmune disorders. © Copyright © 2021 Tang, Wei, Li, Chen, Dai, Lu and Zheng.

基金：

基金编号： No. 2019KTSCX025

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2019]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 5.085 出版当年[2019版] 5.733 出版当年五年平均 4.716 出版前一年[2018版] 7.561 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Pharmacology of Traditional Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China,

共同第一作者：

通讯作者：

通讯机构： [1]Department of Pharmacology of Traditional Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China, [7]Department of Pathology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs. [2]Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? [3]Antitumor effects of immunity-enhancing traditional Chinese medicine [4]Antitumor effects of immunity-enhancing traditional Chinese medicine [5]Effects of Cigarette Smoking on Transplant Survival: Extending or Shortening It? [6]N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression [7]FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression [8]Difference in Pathomechanism Between Crohn's Disease and Ulcerative Colitis Revealed by Colon Transcriptome [9]The prognostic value and multiomic features of m6A-related risk signature in lung adenocarcinoma [10]The m6A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m6A-Dependent Manner

日	一	二	三	四	五	六

今天

清空