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Qualitative and quantitative analysis of the chemical profile for Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula for the treatment of coronary heart disease, by UPLC-Q/TOF-MS combined with chemometric analysis

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收录情况： ◇ SCIE

作者：
Lin, P[a] * ; Wang, Q[a] * ; Liu, Y[a] ; Jiang, H[a,b] ; Lv, W[b] ; Lan, T[b] ; Qin, Z[a,c,*1] ; Yao, X[a,d] ; Yao, Z[a,d,*1] ;
机构： [a]College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [b]Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, PR China [c]Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China [d]International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE), School of Pharmacy, Jinan University, Guangzhou, 510632, PR China
出处：
DOI： 10.1016/j.jpba.2021.113950
ISSN：

关键词： Chemical profile Chemometric analysis Coronary heart disease Gualou-Xiebai-Banxia decoction Pinellinae Rhizoma Praeparatum

摘要：
Gualou-Xiebai-Banxia decoction (GXB) is one of the famous classical traditional Chinese Medicine (TCM) formula for the treatment of chest stuffiness and pains syndrome in Chinese medicine, i.e., coronary heart disease (CHD) in modern medicine. Being compared with Gualou-Xiebai Baijiu-decoction which only consists of Trichosanthis Pericarpium (TP), Allii Macrostemonis Bulbus (AMB) and wine, GXB is composed of another one additional herbal medicine, Pinellinae Rhizoma Praeparatum (PRP), and is more suitable to treat severe atherosclerosis and dyslipidemia. However, the comprehensive chemical composition of GXB is still unclear, which has seriously hindered the discovery of its effective components for improving the clinical symptoms of CHD. The present study aimed to investigate the overall chemical profile of GXB qualitatively and quantitatively by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS), and further explore the chemical contribution of PRP to this formula combined with chemometric approach. First, a total of 151 components, including steroidal saponins, flavonoids, triterpenoids, nitrogenous and other types components, were detected and characterized by UPLC-Q/TOF-MS in GXB. Then, flavonoids and nitrogenous could be qualitatively observed enrichment in GXB compared to those in GXB-dePRP (GXB deducted PRP in the formula). Furthermore, 19 characteristic components were selected for quantitative comparison between GXB and GXB-dePRP by UPLC-MS/MS combined with chemometric method. These findings indicated that steroidal saponins were the most abundant components in GXB, while the introduction of PRP could not only enrich the structural types of chemical compounds in this formula, but also increase the abundance of active components from other composed herbal medicines, TP and AMB. Taken together, this study developed and validated sensitive and practical methods for qualitative and quantitative analysis of GXB, and clarified the chemical contribution of PRP to this formula. These results laid a solid chemical foundation for further in vivo disposal investigation to screen out the potential effective components as well as therapeutic mechanism research of GXB. © 2021

基金：
National Key R&D Program ofChina (2017YFC1700400, 2017YFC1700405); the National NaturalScience Foundation of China (81773880); the Key Project of First-class University Construction of Guangzhou University of ChineseMedicine (XK2019024) and the National Major Scientific and Pro-gram of Introducing Talents of Discipline to Universities (B13038).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 分析化学 3 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 分析化学 3 区 药学
JCR分区：
出版当年[2019]版：
Q2 PHARMACOLOGY & PHARMACY Q2 CHEMISTRY, ANALYTICAL
最新[2023]版：
Q2 CHEMISTRY, ANALYTICAL Q2 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]College of Pharmacy, Jinan University, Guangzhou, 510632, PR China
共同第一作者：
通讯作者：
通讯机构： [a]College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [c]Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China [d]International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE), School of Pharmacy, Jinan University, Guangzhou, 510632, PR China [*1]College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
推荐引用方式(GB/T 7714)：
Lin P,Wang Q,Liu Y,et al.Qualitative and quantitative analysis of the chemical profile for Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula for the treatment of coronary heart disease, by UPLC-Q/TOF-MS combined with chemometric analysis[J].JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2021,197:doi:10.1016/j.jpba.2021.113950.
APA：
Lin, P,Wang, Q,Liu, Y,Jiang, H,Lv, W...&Yao, Z.(2021).Qualitative and quantitative analysis of the chemical profile for Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula for the treatment of coronary heart disease, by UPLC-Q/TOF-MS combined with chemometric analysis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,197,
MLA：
Lin, P,et al."Qualitative and quantitative analysis of the chemical profile for Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula for the treatment of coronary heart disease, by UPLC-Q/TOF-MS combined with chemometric analysis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 197.(2021)

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