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Effectiveness and safety of Chinese herbal medicine formula Gualou Xiebai Banxia (GLXBBX) decoction for the treatment of stable angina pectoris Protocol for a systematic review(Open Access)

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机构: [a]Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, [b]Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, [c]Fuwai Hospital Chinese Academy of Medical Sciences, Beijing, China.
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关键词: Chinese herbal medicine Gualou Xiebai Banxia decoction Protocol Stable angina pectoris Systematic review

摘要:
Background: Stable angina pectoris (SAP) is one of the most common symptoms of coronary heart disease. Chinese herbal medicine (CHM) has been used to treat SAP increasingly due to its less side effects. The subject of this study is to explore the effectiveness and safety of Gualou Xiebai Banxia (GLXBBX) decoction as a kind of CHM for SAP. Methods: A systematic literature search for articles up to June 2018 will be performed in following electronic databases: PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Chinese Biomedical Database, Chinese Biomedical Literature Service System (SinoMed), and Wanfang Database. Inclusion criteria are randomized controlled trials of modified GLXBBX decoction applied on patients with SAP. The primary outcome measures will be coronary heart disease-related clinical evaluation (frequency of acute attack angina, severity of angina pectoris, electrocardiographic changes, and amount of nitroglycerin) and adverse events. RevMan 5.3 software will be used for data synthesis, sensitivity analysis, metaregression, subgroup analysis, and risk of bias assessment. A funnel plot will be developed to evaluate reporting bias and Egger tests will be used to assess funnel plot symmetries. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Results: This systematic review study will provide an evidence of GLXBBX decoction for SAP. Conclusion: The study will give an explicit evidence to evaluate the effectiveness and safety of GLXBBX decoction for SAP. Ethics and dissemination: This systematic review does not require ethics approval and will be submitted to a peer-reviewed journal. PROSPERO registration number: CRD 42018094538. Abbreviations: CHD = coronary heart disease, CHM = Chinese herbal medicine, CI = confidence interval, ECG = electrocardiogram, GLXBBX = Gualou Xiebai Banxia, PRISMA-P = Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, PROSPERO = prospective register of systematic review, RCT = randomized controlled trial, RR = risk ratio, SAP = stable angina pectoris, SinoMed = Chinese Biomedical Literature Service System, SMD = standardized mean difference, WMD = weighted mean difference. Copyright © 2018 the Author(s).

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出版当年[2017]版:
大类 | 3 区 医学
小类 | 3 区 医学:内科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
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出版当年[2016]版:
Q2 MEDICINE, GENERAL & INTERNAL
最新[2024]版:
Q2 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2024版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [a]Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine,
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通讯机构: [a]Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, [*1]Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
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