机构：[1]Departments of Respriratory and Critical Care Medicine, Chronic Airways Diseases Laboratory,Nanfang Hospital, Southern Medical University ,Guangzhou,China[2]Department of Respiratory Medicine, The Sixth Affiliated Hospital of Guangzhou MedicalUniversity, Qingyuan People' s Hospital, Qingyuan, China[3]Department of Critical Care Medicine, The Second Afiliated Hospital of Guangzhou University ofChinese Medicine, Guangzhou, China.
Alamandine (ALA) and its receptor MrgD were recently identified as components of the renin-angiotensin system (RAS), which confer protection against cardio-fibrosis and renal-fibrosis. However, the effects of ALA on pulmonary fibrosis are unknown. This study was designed to serve two goals: (1) to evaluate ALA/MrgD axis ability in the prevention of Angiotensin Ⅱ (Ang Ⅱ)-induced pulmonary fibrosis in fibroblasts. (2) to determine the effect of ALA in bleomycin (BLM) treated C57B/6 mice. In vivo experiments revealed that the treatment of C57B/6 mice with ALA prevented BLM-induced fibrosis and these findings were similar to those reported for pirfenidone. The anti-fibrosis actions of ALA were mediated via alleviation of oxidative injury and autophagy induction. In addition, in vitro studies revealed that ALA treatment attenuated Ang Ⅱ-induced α-collagen I, CTGF and α-SMA production in fibroblast which was blocked by D-Pro7-Ang-(1-7), an MrgD antagonist. This led to alleviation of oxidative injury and induction of autophagy similar to that reported for rapamycin. This study demonstrated that ALA via MrgD receptor reduced pulmonary fibrosis through attenuation of oxidative injury and induction of autophagy.
第一作者机构：[1]Departments of Respriratory and Critical Care Medicine, Chronic Airways Diseases Laboratory,Nanfang Hospital, Southern Medical University ,Guangzhou,China[2]Department of Respiratory Medicine, The Sixth Affiliated Hospital of Guangzhou MedicalUniversity, Qingyuan People' s Hospital, Qingyuan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Qingxia,Zheng Bojun,Zhang Yue,et al.Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway.[J].CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.2021,99(9):885-899.doi:10.1139/cjpp-2020-0662.
APA：
Liu Qingxia,Zheng Bojun,Zhang Yue,Huang Wenhui,Hong Qiaohui&Meng Ying.(2021).Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway..CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,99,(9)
MLA：
Liu Qingxia,et al."Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway.".CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 99..9(2021):885-899
