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Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Ling[a,b,e] * ; Wu Yu-Ting[a,b] * ; Gu Xuan-Ye[a,g] * ; Xie Ling-Peng[a,b] ; Fan Hui-Jie[a,b] ; Tan Zhang-Bin[a,b,d] ; Zhang Wen-Tong[a,b] ; Chen Hong-Mei[a,b,c] ; Li Jun[a,b] ; Huang Gui-Qiong[f] ; Liu Bin[a,b,d,*1] ; Zhou Ying-Chun[a,b,c,*1] ; Sun Xiao-Min[a,b,*1] ;
机构： [a]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [b]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China [c]Department of Traditional Chinese Medicine, Nanfang Hospital (Zengcheng Branch), Southern Medical University, Guangzhou 511300, China [d]Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China [e]Department of Comprehensive Medicine, Guangdong Jiangnan Hospital (Guangdong Provincial Social Welfare Service Center), Guangzhou 510220, China [f]Department of Internal Medicine, Huizhou Hospital of Guangzhou University of Traditional Chinese Medicine, Huizhou 516000, China [g]Boxing County Hospital of Traditional Chinese Medicine, Binzhou 256500, China
出处：
DOI： 10.1016/j.bmcl.2021.128045
ISSN：

关键词： Aldehyde dehydrogenase 2 Magnolol Myocardial fibrosis Proliferation Collagen synthesis

摘要：
Inhibiting myocardial fibrosis can help prevent cardiovascular diseases, including heart failure. Magnolol (Mag), a natural component of Magnoliae officinalis, has been reported to inhibit fibrosis. However, the mechanism of Mag activity and its effects on myocardial fibrosis remain unclear. Here, we investigated the involvement of ALDH2, an endogenous protective agent against myocardial fibrosis, in the Mag-mediated inhibition of cardiac fibroblast proliferation and collagen synthesis. We found that Mag significantly inhibited cardiac fibroblast proliferation and collagen synthesis, based on the results of MTT, EdU and western blot assays. Moreover, molecular docking, molecular dynamics simulation and surface plasmon resonance (SPR) assays showed that Mag could bind directly and stably to ALDH2. Further analysis of the mechanism of these effects indicated that treatment with Mag dose-dependently enhanced ALDH2 activity without altering protein expression. Mag could enhance the activity of recombinant human ALDH2 proteins with a half-maximal effective concentration of 5.79 × 10-5 M. In addition, ALDH2 activation via Alda-1 inhibited cardiac fibroblast proliferation and collagen synthesis, while ALDH2 inhibition via daidzin partially blocked the suppressive effects of Mag. In summary, Mag may act as a natural ALDH2 agonist and inhibit cardiac fibroblast proliferation and collagen synthesis. Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (81973645, 81673805, 81704058, 82004103 and 81774100), Natural Science Foundation of Guangdong Province (2019A1515011560, 2019B1515120026 and 2019A1515110367), Traditional Chinese Medicine Bureau of Guangdong Province (20173016 and 20201392), Project of Huizhou science and Technology Bureau (2016C0408023). Chinese Postdoctoral Science Foundation (2019 M652985), Medical Scientific Research Foundation of Guangdong (A2019125).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 有机化学 4 区 药物化学
最新[2025]版：
大类 | 4 区 医学
小类 | 2 区 有机化学 4 区 药物化学
JCR分区：
出版当年[2019]版：
Q2 CHEMISTRY, ORGANIC Q3 CHEMISTRY, MEDICINAL
最新[2023]版：
Q2 CHEMISTRY, ORGANIC Q3 CHEMISTRY, MEDICINAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [b]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China [e]Department of Comprehensive Medicine, Guangdong Jiangnan Hospital (Guangdong Provincial Social Welfare Service Center), Guangzhou 510220, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [b]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China [c]Department of Traditional Chinese Medicine, Nanfang Hospital (Zengcheng Branch), Southern Medical University, Guangzhou 511300, China [d]Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China [*1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
推荐引用方式(GB/T 7714)：
Chen Ling,Wu Yu-Ting,Gu Xuan-Ye,et al.Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts.[J].BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.2021,43:doi:10.1016/j.bmcl.2021.128045.
APA：
Chen Ling,Wu Yu-Ting,Gu Xuan-Ye,Xie Ling-Peng,Fan Hui-Jie...&Sun Xiao-Min.(2021).Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts..BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,43,
MLA：
Chen Ling,et al."Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts.".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 43.(2021)

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