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Regulatory role of long non-coding RNA UCA1 in signaling pathways and its clinical applications.

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收录情况： ◇ SCIE ◇ 预警期刊

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机构： [1]Department of Rheumatology, The First Affiliated Hospital, University of South China,Hengyang, Hunan 421001 [2]Department of Hematology, The First Affiliated Hospital, University of South China,Hengyang, Hunan 421001 [3]Molecular Biology Research Center and Center for Medical Genetics,School of Life Sciences, Central South University, Changsha, Hunan 410078 [4]Department of Clinical Laboratory,Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong 518033, P.R. China

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关键词： lncRNA UCA1 signaling pathway diagnosis prognosis

摘要：

Long non-coding RNA metastasis-associated urothelial carcinoma associated 1 (UCA1) plays a pivotal role in various human diseases. Its gene expression is regulated by several factors, including transcription factors, chromatin remodeling and epigenetic modification. UCA1 is involved in the regulation of the PI3K/AKT, Wnt/β-catenin, MAPK, NF-κB and JAK/STAT signaling pathways, affecting a series of cellular biological functions, such as cell proliferation, apoptosis, migration, invasion and tumor drug resistance. Furthermore, UCA1 is used as a novel potential biomarker for disease diagnosis and prognosis, as well as a target for clinical gene therapy. The present review systematically summarizes and elucidates the mechanisms of upstream transcriptional regulation of UCA1, the regulatory role of UCA1 in multiple signaling pathways in the occurrence and development of several diseases, and its potential applications in clinical treatment. Copyright: © Liu et al.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2019]版：

Q3 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2.5 最新[2023版] 2.4 最新五年平均 2.311 出版当年[2019版] 2.034 出版当年五年平均 1.871 出版前一年[2018版] 2.967 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Rheumatology, The First Affiliated Hospital, University of South China,Hengyang, Hunan 421001

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通讯作者：

通讯机构： [1]Department of Rheumatology, The First Affiliated Hospital, University of South China,Hengyang, Hunan 421001 [4]Department of Clinical Laboratory,Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong 518033, P.R. China [*1]Department of Rheumatology, The First Affiliated Hospital, University of South China, 69 Chuanshan Road, Hengyang, Hunan 421001, P.R. China

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Regulatory role of long non-coding RNA UCA1 in signaling pathways and its clinical applications.

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