机构：[1]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China[2]School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China[3]Shanxi Taihang Pharmaceutical Co., Ltd, Changzhi, Shanxi 046000, China[4]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China广东省中医院深圳市中医院深圳医学信息中心
BACKGROUND: Shanmei Capsule is a famous preparation in China. However, the related mechanism of Shanmei Capsule against hyperlipidemia has yet to be revealed. OBJECTIVE: To elucidate underlying mechanism of Shanmei Capsule against hyperlipidemia through network pharmacology approach and molecular docking. METHODS: Active ingredients, targets of Shanmei Capsule as well as targets for hyperlipidemia were screened based on database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed via Database for Annotation, Visualization, and Integrated Discovery (DAVID) 6.8 database. Ingredient-target-disease-pathway network was visualized utilizing Cytoscape software and molecular docking was performed by Autodock Vina. RESULTS: Seventeen active ingredients in Shanmei Capsule were screened out with a closely connection with 34 hyperlipidemia-related targets. GO analysis revealed 40 biological processes, 5 cellular components and 29 molecular functions. A total of 15 signal pathways were enriched by KEGG pathway enrichment analysis. The docking results indicated that the binding activities of key ingredients for PPAR-alpha are equivalent to that of the positive drug lifibrate. CONCLUSIONS: The possible molecular mechanism mainly involved PPAR signaling pathway, Bile secretion and TNF signaling pathway via acting on MAPK8, PPAR gamma, MMP9, PPAR alpha, FABP4 and NOS2 targets.
基金：
Key Research and Development Program of Shanxi Province [201903D321205]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区工程：生物医学4 区卫生保健与服务
最新[2025]版：
大类|4 区医学
小类|4 区工程：生物医学4 区卫生保健与服务
JCR分区：
出版当年[2019]版：
Q4ENGINEERING, BIOMEDICALQ4HEALTH CARE SCIENCES & SERVICES
最新[2023]版：
Q3HEALTH CARE SCIENCES & SERVICESQ4ENGINEERING, BIOMEDICAL
第一作者机构：[1]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China[2]School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China[*1]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China[*2]School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
推荐引用方式(GB/T 7714)：
Wang Qian,Du Lijing,Hong Jiana,et al.Molecular mechanism underlying the hypolipidemic effect of Shanmei Capsule based on network pharmacology and molecular docking[J].TECHNOLOGY AND HEALTH CARE.2021,29:S239-S256.doi:10.3233/THC-218023.
APA：
Wang, Qian,Du, Lijing,Hong, Jiana,Chen, Zhenlin,Liu, Huijian...&Yan, Shikai.(2021).Molecular mechanism underlying the hypolipidemic effect of Shanmei Capsule based on network pharmacology and molecular docking.TECHNOLOGY AND HEALTH CARE,29,
MLA：
Wang, Qian,et al."Molecular mechanism underlying the hypolipidemic effect of Shanmei Capsule based on network pharmacology and molecular docking".TECHNOLOGY AND HEALTH CARE 29.(2021):S239-S256
