高级检索
当前位置: 首页 > 详情页

Competing-risks nomograms for predicting cause-specific mortality in parotid-gland carcinoma: A population-based analysis.

文献详情

资源类型:
Pubmed体系:
机构: [1]Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China. [2]School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China. [3]Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China. [4]School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
出处:

关键词: cause-specific mortality competing-risks analysis nomogram parotid-gland carcinoma SEER

摘要:
Parotid-gland carcinoma (PGC) is a relatively rare tumor that comprises a group of heterogeneous histologic subtypes. We used the Surveillance, Epidemiology, and End Results (SEER) program database to apply a competing-risks analysis to PGC patients, and then established and validated predictive nomograms for PGC. Specific screening criteria were applied to identify PGC patients and extract their clinical and other characteristics from the SEER database. We used the cumulative incidence function to estimate the cumulative incidence rates of PGC-specific death (GCD) and other cause-specific death (OCD), and tested for differences between groups using Gray's test. We then identified independent prognostic factors by applying the Fine-Gray proportional subdistribution hazard approach, and constructed predictive nomograms based on the results. Calibration curves and the concordance index (C-index) were employed to validate the nomograms. We finally identified 4,075 eligible PGC patients who had been added to the SEER database from 2004 to 2015. Their 1-, 3-, and 5-year cumulative incidence rates of GCD were 10.1%, 21.6%, and 25.7%, respectively, while those of OCD were 2.9%, 6.6%, and 9.0%. Age, race, World Health Organization histologic risk classification, differentiation grade, American Joint Committee on Cancer (AJCC) T stage, AJCC N stage, AJCC M stage, and RS (radiotherapy and surgery status) were independent predictors of GCD, while those of OCD were age, sex, marital status, AJCC T stage, AJCC M stage, and RS. These factors were integrated for constructing predictive nomograms. The results for calibration curves and the C-index suggested that the nomograms were well calibrated and had good discrimination ability. We have used the SEER database to establish-to the best of our knowledge-the first competing-risks nomograms for predicting the 1-, 3-, and 5-year cause-specific mortality in PGC. The nomograms showed relatively good performance and can be used in clinical practice to assist clinicians in individualized treatment decision-making. © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

基金:
语种:
PubmedID:
中科院(CAS)分区:
出版当年[2020]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
第一作者:
第一作者机构: [1]Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China. [2]School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China.
通讯作者:
通讯机构: [1]Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China. [2]School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China. [*1]Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China and School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People’s Republic of China.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:2018 今日访问量:0 总访问量:645 更新日期:2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持:重庆聚合科技有限公司 地址:广州市越秀区大德路111号