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Ultrafast in-situ forming halloysite nanotube-doped chitosan/oxidized dextran hydrogels for hemostasis and wound repair.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ EI

作者：
Li Zhan[1,2] * ; Li Binglin[2] * ; Li Xinrong[1] * ; Lin Zefeng[2] ; Chen Lingling[2] ; Chen Hu[2] ; Jin Yan[2] ; Zhang Tao[2] ; Xia Hong[1,2] ; Lu Yao[2,3,*1] ; Zhang Ying[1,2,*1] ;
机构： [1]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [2]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine of Southern Medical University, Guangzhou 510010, China [3]Department of Joint and Orthopedics, Orthopedic Center, Clinical Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
出处：
DOI： 10.1016/j.carbpol.2021.118155
ISSN：

关键词： Adhesive hydrogel Hemostasis Antibacterial ability Wound healing

摘要：
A series of halloysite nanotube (HNT)-doped chitosan (CS)/oxidized dextran (ODEX) adhesive hydrogels were developed through a Schiff base reaction. The resultant CS/ODEX/HNT hydrogels could not only form in situ on wounds within only 1 s when injected, but could also adapt to wounds of different shapes and depths after injection. We established four rat and rabbit hemorrhage models and demonstrated that the hydrogels are better than the clinically used gelatin sponge for reducing hemostatic time and blood loss, particularly in arterial and deep noncompressible bleeding wounds. Moreover, the natural antibacterial features of CS and ODEX provided the hydrogels with strong bacteria-killing effects. Consequently, they significantly promoted methicillin-resistant Staphylococcus aureus -infected-wound repair compared to commercial gelatin sponge and silver-alginate antibacterial wound dressing. Hence, our multifunctional hydrogels with facile preparation process and utilization procedure could potentially be used as first-aid biomaterials for rapid hemostasis and infected-wound repair in emergency injury events.Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
Research Program of PLA (20WQ030, 20QNPY083, CGZ16C004), the National Natural Science Foundation of China (81902198 and 81972080), the Science and Technology Planning Project of Guangdong Province (2017B030314139), the Natural Science Foundation of Guangdong Province (2015A030312004 and 2020A1515010398), the Science and Technology Planning Project of Guangzhou (202002030304), Medical Research Foundation of Guangdong Province (A2019228), China Postdoctoral Science Foundation (BX20190150 and 2019M662980), President Foundation of Zhujiang Hospital, Southern Medical University (yzjj2018rc09), and Scientific Research Foundation of Southern Medical University (C1051353 and PY2018N060).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 工程技术
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
最新[2025]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
JCR分区：
出版当年[2019]版：
Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE
最新[2023]版：
Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [2]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine of Southern Medical University, Guangzhou 510010, China
共同第一作者：
通讯作者：
通讯机构： [1]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [2]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine of Southern Medical University, Guangzhou 510010, China [3]Department of Joint and Orthopedics, Orthopedic Center, Clinical Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China [*1]Department of Joint and Orthopedics, Orthopedic Center, Clinical Research Center, Zhujiang Hospital, 253 Gongye Road, Guangzhou 510282, China
推荐引用方式(GB/T 7714)：
Li Zhan,Li Binglin,Li Xinrong,et al.Ultrafast in-situ forming halloysite nanotube-doped chitosan/oxidized dextran hydrogels for hemostasis and wound repair.[J].CARBOHYDRATE POLYMERS.2021,267:doi:10.1016/j.carbpol.2021.118155.
APA：
Li Zhan,Li Binglin,Li Xinrong,Lin Zefeng,Chen Lingling...&Zhang Ying.(2021).Ultrafast in-situ forming halloysite nanotube-doped chitosan/oxidized dextran hydrogels for hemostasis and wound repair..CARBOHYDRATE POLYMERS,267,
MLA：
Li Zhan,et al."Ultrafast in-situ forming halloysite nanotube-doped chitosan/oxidized dextran hydrogels for hemostasis and wound repair.".CARBOHYDRATE POLYMERS 267.(2021)

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