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Recent pharmacological advances in the repurposing of artemisinin drugs.

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机构: [1]Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China [2]Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [3]Center for Reproductive Medicine, Dongguan Maternal And Child Health Care Hospital, Southern Medical University, Dongguan, China [4]Oncology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [5]Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China [6]Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China [7]Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China
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关键词: artemisinins autoimmune disorder cancer infection inflammation

摘要:
Artemisinins are a family of sesquiterpene lactones originally derived from the sweet wormwood (Artemisia annua). Beyond their well-characterized role as frontline antimalarial drugs, artemisinins have also received increased attention for other potential pharmaceutical effects, which include antiviral, antiparsitic, antifungal, anti-inflammatory, and anticancer activities. With concerted efforts in further preclinical and clinical studies, artemisinin-based drugs have the potential to be viable treatments for a great variety of human diseases. Here, we provide a comprehensive update on recent reports of pharmacological actions and applications of artemisinins outside of their better-known antimalarial role and highlight their potential therapeutic viability for various diseases.© 2021 Wiley Periodicals LLC.

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出版当年[2020]版
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 药学
最新[2025]版
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 药学
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第一作者机构: [1]Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
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通讯机构: [1]Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China [3]Center for Reproductive Medicine, Dongguan Maternal And Child Health Care Hospital, Southern Medical University, Dongguan, China [4]Oncology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [5]Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China [6]Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China [7]Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China [*1]Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China [*2]Center for Reproductive Medicine, Dongguan Maternal And Child Health Care Hospital, Southern Medical University, Dongguan 523000, China [*3]Oncology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
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