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Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Yunjia[1,2] * ; Song Yuhong[3] * ; Deng Guanghui[2] * ; Tan Qinxiang[3] * ; Xu Shu[4] ; Yang Menghan[2] ; Shi Hao[2] ; Hong Mukeng[2] ; Ye Haixin[2] ; Wu Chaofeng[2] ; Ma Shuoyi[5] ; Huang Huacong[2] ; Zhang Yanhong[5] ; Zeng Zhiyun[2] ; Wang Ming[1,2] ; Chen Yuyao[2] ; Wang Yunqing[7] ; Ma Jun[5,*3] ; Li Juan[6,*2] ; Gao Lei[1,2,*1] ;
机构： [1]Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510000, Guangdong, China [3]Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, 518116, Guangdong, China [4]Department of Oncology, Shenzhen Hospital, University of Chinese Academy of Sciences, Shenzhen, 518107, Guangdong, China [5]Department of Traditional Chinese Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, 510000, Guangdong, China [6]Department of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, Guangdong, China [7]Fifth People’s Hospital, Yuhang District, Hangzhou, 311100, Zhejiang, China
出处：
DOI： 10.1016/j.freeradbiomed.2021.07.008
ISSN：

关键词： Acute liver failure Indoleamine 2 3-dioxygenase 1 Iron Transferrin Nitrative stress

摘要：
Acetaminophen (APAP) is the leading cause of acute liver failure (ALF), which is characterized by GSH depletion, oxidative stress and mitochondrial dysfunction. However, the specific mechanism of APAP-induced ALF remains to be clarified. In this study, we demonstrated that indoleamine 2,3-dioxygenase 1 (IDO1) aggravated APAP-induced ALF associated with excess lipid peroxidation, which was reversed by lipid peroxidation inhibitor (ferrostatin-1). Meanwhile, IDO1 deficiency effectively decreased the accumulation of reactive nitrogen species. Additionally, IDO1 deficiency prevented against APAP-induced liver injury through suppressing the activation of macrophages, thereby reduced their iron uptake and export, eventually reduced iron accumulation in hepatocytes through transferrin and transferrin receptor axis. In summary, our study confirmed that APAP-induced IDO1 aggravated ALF by triggering excess oxidative and nitrative stress and iron accumulation in liver. These results offer new insights for the clinical treatment of ALF or iron-dysregulated liver diseases in the future.Copyright © 2021 Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (81774170, 82074131, 82000595 and 81774035), the Natural Science Foundation of Guangdong Province (2018B030306012), the Scientific Research Initiative Program of Southern Medical University (CX2017N001), and Shenzhen Guangming District health system research project (2020R01126).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 生化与分子生物学 2 区 内分泌学与代谢
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 内分泌学与代谢
JCR分区：
出版当年[2019]版：
Q1 ENDOCRINOLOGY & METABOLISM Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510000, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510000, Guangdong, China [5]Department of Traditional Chinese Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, 510000, Guangdong, China [6]Department of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, Guangdong, China [*1]Zhujiang Hospital, Southern Medical University (SMU), Sha Tai Nan Road No. 1063, Guangzhou, Guangdong, 510515, China. [*2]Department of traditional Chinese medicine, Guangzhou First People’s Hospital, Guangzhou, Guangdong, 510000, China. [*3]Department of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
推荐引用方式(GB/T 7714)：
Li Yunjia,Song Yuhong,Deng Guanghui,et al.Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation.[J].FREE RADICAL BIOLOGY AND MEDICINE.2021,172:578-589.doi:10.1016/j.freeradbiomed.2021.07.008.
APA：
Li Yunjia,Song Yuhong,Deng Guanghui,Tan Qinxiang,Xu Shu...&Gao Lei.(2021).Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation..FREE RADICAL BIOLOGY AND MEDICINE,172,
MLA：
Li Yunjia,et al."Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation.".FREE RADICAL BIOLOGY AND MEDICINE 172.(2021):578-589

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