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Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.

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收录情况： ◇ SCIE

作者：
Yang Bowen[1,2,3] * ; Peng Fu[4] * ; Zhang Yu[3] ; Wang Xuan[1] ; Wang Shengqi[1,5,6] ; Zheng Yifeng[1] ; Zhang Juping[1] ; Zeng Yihao[3] ; Wang Neng[3,6] ; Peng Cheng[2] ; Wang Zhiyu[1,2,3,5,6] ;
机构： [1]The Research Center of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Chinese Medicine, Chengdu, Sichuan, China [3]The Research Center for Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [4]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu, China [5]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China [6]Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
出处：
DOI： 10.1016/j.phymed.2021.153628
ISSN：

关键词： Aiduqing formula Breast cancer Metastasis CXCL1 Autophagy

摘要：
Metastasis is the most common lethal cause of breast cancer-related death. Recent studies have implied that autophagy is closely implicated in cancer metastasis. Therefore, it is of great significance to explore autophagy-related molecular targets involved in breast cancer metastasis and to develop therapeutic drugs.This study was designed to investigate the anti-metastatic effects and autophagy regulatory mechanisms of Aiduqing (ADQ) formula on breast cancer.Multiple cellular and molecular experiments were conducted to investigate the inhibitory effects of ADQ formula on autophagy and metastasis of breast cancer cells in vitro. Meanwhile, autophagic activator/inhibitor as well as CXCL1 overexpression or interference plasmids were used to investigate the underlying mechanisms of ADQ formula in modulating autophagy-mediated metastasis. Furthermore, the zebrafish xenotransplantation model and mouse xenografts were applied to validate the inhibitory effect of ADQ formula on autophagy-mediated metastasis in breast cancer in vivo.ADQ formula significantly inhibited the proliferation, migration, invasion and autophagy but induced apoptosis of high-metastatic breast cancer cells in vitro. Similar results were also observed in starvation-induced breast cancer cells which exhibited elevated metastatic ability and autophagy activity. Mechanism investigations further approved that either CXCL1 overexpression or autophagic activator rapamycin can significantly abrogated the anti-metastatic effects of ADQ formula, suggesting that CXCL1-mediated autophagy may be the crucial pathway of ADQ formula in suppressing breast cancer metastasis. More importantly, ADQ formula suppressed breast cancer growth, autophagy, and metastasis in both the zebrafish xenotransplantation model and the mouse xenografts.Our study not only revealed the novel function of CXCL1 in mediating autophagy-mediated metastasis but also suggested ADQ formula as a candidate drug for the treatment of metastatic breast cancer.Copyright © 2021. Published by Elsevier GmbH.

基金：
National Natural Science Foundation of China [82004132, 82074165, 82004373, 81873306, 81973526]; Science and Technology Planning Project of Guangdong Province [2021A0505030059, 2017B030314166, 2016A030306025]; Department of Education of Guangdong Province [2018KZDXM022, A1-2606- 19-111-009, 2019KQNCX019]; The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab) [2020B1212030006]; Guangdong traditional Chinese medicine bureau project [20201132, 20211114]; the Ph.D. Start-up Fund of Natural Science Foundation of Guangdong Province [2018A030310506]; Guangzhou science and technology project [202102010316, 201904010407]; The Specific Research Fund for TCM Science and Technology of Guangdong provincial Hospital of Chinese Medicine [YN2018MJ07, YN2018QJ08], and the Foundation for Young Scholars of Guangzhou University of Chinese Medicine [QNYC20190101].
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 1 区 全科医学与补充医学 2 区 药物化学 2 区 药学 2 区 植物科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
JCR分区：
出版当年[2019]版：
Q1 PLANT SCIENCES Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]The Research Center of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Chinese Medicine, Chengdu, Sichuan, China [3]The Research Center for Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]The Research Center of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Chinese Medicine, Chengdu, Sichuan, China [3]The Research Center for Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [5]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China [6]Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
推荐引用方式(GB/T 7714)：
Yang Bowen,Peng Fu,Zhang Yu,et al.Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.[J].PHYTOMEDICINE.2021,90:doi:10.1016/j.phymed.2021.153628.
APA：
Yang Bowen,Peng Fu,Zhang Yu,Wang Xuan,Wang Shengqi...&Wang Zhiyu.(2021).Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy..PHYTOMEDICINE,90,
MLA：
Yang Bowen,et al."Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.".PHYTOMEDICINE 90.(2021)

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