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Feasibility and Preliminary Effects of the BESMILE-HF Program on Chronic Heart Failure Patients: A Pilot Randomized Controlled Trial

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机构: [1]Health Systems and Policy, Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden, [2]Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, [4]Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, [5]Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, United States, [6]National Centre for Design Measurement and Evaluation in Clinical Research, Guangzhou University of Chinese Medicine, Guangzhou, China, [7]Heart Failure Center/Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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关键词: exercise-based cardiac rehabilitation chronic heart failure pilot randomized controlled trial self-efficacy for exercise Baduanjin exercise

摘要:
Aims: The Baduanjin Eight-Silken-Movements wIth Self-Efficacy building for Heart Failure (BESMILE-HF) program is a contextually adapted cardiac rehabilitation program. It uses a traditional Chinese exercise, Baduanjin, to solve the unmet demand of exercise-based cardiac rehabilitation programs due to their scarcity and unaffordability in China. This pilot study assesses BESMILE-HF's feasibility and preliminary effects. Methods: Eighteen patients with chronic heart failure were included: 8 in a BESMILE-HF group (age: 67 +/- 5 years, EF: 40.4 +/- 13.6%) and 10 in a control group (age: 70 +/- 13 years, EF: 42.9 +/- 12.5%). Both received the usual medications, with the intervention group receiving additionally the BESMILE-HF program for 6 weeks. Feasibility was explored by participants' involvement in the intended intervention. Clinical outcome assessments were conducted at baseline and post-intervention, while adverse events were captured throughout the study period. Results: The BESMILE-HF program was well-received by patients, and adherence to the intervention was good. The intervention group completed all required home exercises and total home-practice time was correlated with baseline self-efficacy (r = 0.831, p = 0.011). Moreover, after 6 weeks, self-efficacy increased in the BESMILE-HF group (p = 0.028) and the change was higher than in the control [mean difference (MD): 3.2; 95% confidence interval (CI) 0.6-5.9, p = 0.004]. For the exercise capacity, the control group demonstrated a significant decline in peak oxygen consumption (p =0.018) whereas, the BESMILE-HF group maintained their exercise capacity (p = 0.063). Although the between-group difference was not statistically significance, there was clear clinical improvement in the BESMILE-HF group (1.5 mL/kg/min, 95% CI, -0.3 to 3.2 vs. minimal clinically important difference of 1 mL/kg/min). Throughout the study period, no adverse events related to the intervention were captured. Conclusions: BESMILE-HF is feasible for patients with chronic heart failure in Chinese settings. A larger sample size and a longer follow-up period is needed to confirm its benefit on clinical outcomes.

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基金编号: YN2018ML02

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 3 区 心脏和心血管系统
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 心脏和心血管系统
JCR分区:
出版当年[2019]版:
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版:
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Health Systems and Policy, Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden, [2]Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China,
通讯作者:
通讯机构: [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, [4]Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, [7]Heart Failure Center/Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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