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Water-soluble matrine-type alkaloids with potential anti-neuroinflammatory activities from the seeds of Sophora alopecuroides.

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资源类型：
Pubmed体系：
作者：
Luo Ding[1] * ; Lin Qiang[1] ; Tan Jin-Lin[1] ; Zhao Hai-Yue[1] ; Feng Xiao[2] ; Chen Neng-Hua[1] ; Wu Zhong-Nan[1] ; Fan Chun-Lin[1] ; Li Yao-Lan[1] ; Ding Wei-Long[3] ; Xiao Fei[2] ; Wang Guo-Cai[1] ; Zhang Yu-Bo[1,2,*1] ;
机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of China [2]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, People’s Republic of China [3]Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People’s Republic of China
出处：
DOI： 10.1016/j.bioorg.2021.105337
ISSN：

关键词： Sophora alopecuroides Matrine-type alkaloid Anti-neuroinflammatory activity Structural modification Structure-activity relationship NF-κB signaling pathway

摘要：
A phytochemical investigation on the alkaloids from water-soluble part of Sophora alopecuroides led to obtain forty matrine-type alkaloids (1-40) including eighteen new ones (1-18), which covers almost all positions of the oxygen substitution in matrine-type structure. Notably, eight compounds (1-8) belong to rare bis-amide matrine-type alkaloid. The new structures were determined based on extensive spectroscopic data, electronic circular dichroism (ECD) calculations, and six instances, verified by X-ray crystallography. Most of isolates showed anti-neuroinflammatory activities based on the expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in BV2 microglia cells. Especially, compound 39 can suppress those two mediator secretions in a dose-dependent manner with IC50 values of 21.6 ± 0.5 and 16.7 ± 0.8 μM, respectively. Further mechanistic study revealed that 39 suppressed the phosphorylation of IκBα and p65 subunit to regulate the NF-κB signaling pathway.Copyright © 2021 Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (nos. 81803376, 82074116, 81973190, 82003609), the Guangdong Basic and Applied Basic Research Foundation (no. 2020B1515020033, 2020A1515110453), the Natural Science Foundation of Guangdong Province (no. 2018B030311020), the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y036), Guangdong Basic and Applied Basic Research Foundation-Regional Joint Fund (Youth Fund Project, no. 2020A1515110415), China Postdoctoral Science (2019 M66340), and the high performance public computing service platform of Jinan University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 化学
小类 | 2 区 有机化学 3 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 有机化学 2 区 生化与分子生物学
第一作者：
第一作者机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of China
通讯作者：
通讯机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of China [2]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, People’s Republic of China [*1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of China
推荐引用方式(GB/T 7714)：
Luo Ding,Lin Qiang,Tan Jin-Lin,et al.Water-soluble matrine-type alkaloids with potential anti-neuroinflammatory activities from the seeds of Sophora alopecuroides.[J].Bioorganic chemistry.2021,116:105337.doi:10.1016/j.bioorg.2021.105337.
APA：
Luo Ding,Lin Qiang,Tan Jin-Lin,Zhao Hai-Yue,Feng Xiao...&Zhang Yu-Bo.(2021).Water-soluble matrine-type alkaloids with potential anti-neuroinflammatory activities from the seeds of Sophora alopecuroides..Bioorganic chemistry,116,
MLA：
Luo Ding,et al."Water-soluble matrine-type alkaloids with potential anti-neuroinflammatory activities from the seeds of Sophora alopecuroides.".Bioorganic chemistry 116.(2021):105337

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