Identification of ferroptosis-associated genes exhibiting altered expression in response to cardiopulmonary bypass during corrective surgery for pediatric tetralogy of fallot.
机构：[1]Department of Anesthesiology, The First Affiliated Hospital, Jinan University, Guangzhou, China[2]Department of Anesthesiology, Macheng People’s Hospital of Macheng, Hubei, China[3]Deparment of Lacrimal, Aier Eye Hospital, Nanning, Guangxi, China[4]Guangxi School of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China[5]Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China[6]Zhanjiang Han Mei plastic surgery hospital, Zhanjiang, Guangdong, China[7]Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Tetralogy of Fallot (ToF) is a life-threatening congenital cardiovascular disorder. Currently, the most effective therapeutic intervention for pediatric ToF remains corrective surgery with cardiopulmonary bypass (CPB). Ferroptosis is an iron-dependent form of regulated cell death, driven by an accumulation of lipid peroxides to levels sufficient to trigger cell death. Ferroptosis was recently linked to cardiac ischemia and reperfusion injury. However, few studies have examined CPB-associated ferroptosis.In the current study, pediatric ToF patient pre- and post-CPB atrial biopsy gene expression profiles were downloaded from a public database, and 117 differentially expressed genes (DEGs) were identified using the Wilcoxon rank-sum test and weighted gene correlation network analysis. These were screened for ferroptosis-associated genes using the FerrDb database, thereby identifying ten genes. Finally, the construction of gene-microRNA (miRNA) and gene-transcription factor (TF) networks, in conjunction with gene ontology and biological pathway enrichment analysis, were used to inform hypotheses regarding the molecular mechanisms underlying CPB-associated ferroptosis.Ten genes involved in CPB-associated ferroptosis(ATF3,TNFAIP3，CDKN1A, ZFP36, JUN，SLC2A3, IL6, CXCL2, PTGS2, and DDIT3). Ferroptosis-associated genes were largely involved in myocardial inflammatory responses and may be regulated by a number of identified miRNAs and TFs, thereby suggesting modulatable pathways potentially involved in CPB-associated ferroptosis.Results suggest that CPB precipitates ferroptosis within cardiac tissue during corrective Surgery for Pediatric Tetralogy of Fallot. These findings may ultimately help improve outcomes of corrective surgery for pediatric ToF.
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外文
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中科院(CAS)分区：
出版当年[2020]版：
大类|4 区综合性期刊
小类|4 区综合性期刊
最新[2025]版：
大类|4 区综合性期刊
小类|4 区综合性期刊
第一作者：
第一作者机构：[1]Department of Anesthesiology, The First Affiliated Hospital, Jinan University, Guangzhou, China
通讯作者：
通讯机构：[1]Department of Anesthesiology, The First Affiliated Hospital, Jinan University, Guangzhou, China[7]Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China[*1]Department of Anesthesiology, The First Affiliated Hospital, Jinan University, 510632, Guangzhou, China
推荐引用方式(GB/T 7714)：
Liu Hongtao,Zhang Bingyong,Chen Shaofeng,et al.Identification of ferroptosis-associated genes exhibiting altered expression in response to cardiopulmonary bypass during corrective surgery for pediatric tetralogy of fallot.[J].Science progress.2021,104(4):368504211050275.doi:10.1177/00368504211050275.
APA：
Liu Hongtao,Zhang Bingyong,Chen Shaofeng,Zhang Yun,Ye Xin...&Zhang Liangqing.(2021).Identification of ferroptosis-associated genes exhibiting altered expression in response to cardiopulmonary bypass during corrective surgery for pediatric tetralogy of fallot..Science progress,104,(4)
MLA：
Liu Hongtao,et al."Identification of ferroptosis-associated genes exhibiting altered expression in response to cardiopulmonary bypass during corrective surgery for pediatric tetralogy of fallot.".Science progress 104..4(2021):368504211050275
