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Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis.

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机构： [a]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China [b]Animal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China [c]Plateau Brain Science Research Center, Tibet University, Lhasa 850012, China [d]Plateau Brain Science Research Center, South China Normal University, Guangzhou 510631, China [e]College of Life Sciences, China West Normal University，Nanchong，Sichuan, China [f]Guangzhou Beneco biotechnology Co. Ltd., Guangzhou, China [g]School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, China [h]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China

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关键词： 16S rRNA sequencing Fluoride-induced damages Gut microbota Probiotics Renal dysfunction

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Fluoride (F) exposure was widely reported to be associated with renal diseases. Since absorbed F enters the organism from drinking water mostly through the gastrointestinal tract, investigating changes of gut microbes may have profound implications for the prevention of chronic F exposure because increasing evidence supported the existence of the gut-kidney axis. In the present study, we aimed to explore the potential positive effects of probiotics on high F exposure-induced renal lesions and dysfunction in mice by the modulation of the colonic microbiota. Mice were fed with normal (Ctrl group) or sodium-fluoride (F and Prob groups; 100 mg/L sodium fluoride (NaF)) drinking water with or without Lactobaillus johnsonii BS15, a probiotic strain proven to be preventive for F exposure. Mice fed with sodium-fluoride drinking water alone exhibited renal tissue damages, decreased the renal antioxidant capability and dysfunction. In contrast, L. johnsonii BS15 reversed these F-induced renal changes. 16S rRNA gene sequencing shows that L. johnsonii BS15 alleviated the increased community diversity (Shannon diversity) and richness index (number of observed features) as well as the distured structure of colon microbiota in F-exposed mice. A total of 13 OTUs with increased relative abundance were identified as the keystone OTUs in F-exposed mice based on the analysis of degree of co-occurrence and abundance of OTUs. Moreover, Spearman's rank correlation shows that the 13 keystone OTUs had negative effect on renal health and intestinal integrity. L. johnsonii BS15 reversed four of keystone OTUs (OTU 5, OTU 794, OTU 1035, and OTU 868) changes which might be related to the underlying protected mechanism of L. johnsonii BS15 against F-induced renal damages.Copyright © 2021. Published by Elsevier Inc.

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出版当年[2020]版：

大类 | 2 区环境科学与生态学

小类 | 2 区环境科学 2 区毒理学

最新[2025]版：

大类 | 2 区环境科学与生态学

小类 | 1 区毒理学 2 区环境科学

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第一作者机构： [a]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China

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通讯机构： [a]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China [b]Animal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China [*1]211 Huimin Road, Chengdu 610400, Sichuan, China. [*2]1838 Guangzhou Avenue, Guangzhou 510000, Guangdong, China.

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Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis.

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