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Influence of fluid balance on the prognosis of patients with sepsis.

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机构： [1]Intensive Care Unit, The First Afliated Hospital of Jinan University, 510630 Guangzhou, Guangdong Province, People’s Republic of China [2]Department of Clinical Research, The First Afliated Hospital of Jinan University, Guangzhou, Guangdong Province, China [3]School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi Province, China [4]Department of Orthopaedics, The First Afliated Hospital of Jinan University, Guangzhou, Guangdong Province, China [5]School of Public Health, Shannxi University of Chinese Medicine, Xianyang, Shaanxi Province, China

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关键词： sepsis eICU-CRD Fluid balance Prognosis

摘要：

Early and timely fluid treatment or resuscitation are the basic measures for the active treatment of sepsis. Our aim is to further explore the relationship between fluid balance and prognosis in patients with sepsis on a daily basis for 5 days.Sepsis patients in eICU Collaborative Research Database were divided into the negative balance group (NB/-) and the positive balance group (PB/+) according to daily fluid balance. The primary outcome was in-hospital mortality. Survival differences between the groups were analyzed by using Cox regression. Then dose-response relationship between fluid balance and in-hospital mortality was studied using restricted cubic splines (RCSs). Furthermore, patients with fluid balance data for the previous three consecutive days were selected and divided into eight groups ("+/+/+", "+/+/-", "+/ -/-", "+/ -/+", "-/ -/-", "-/ -/+", "-/+/+", and "-/+/-"). Kaplan-Meier curves and Cox regression were used to show the survival difference between groups.Our study, which included 19,557 patients in a multicenter database, showed that positive fluid balances on days 1, 2, and 3 after sepsis diagnosis were associated with poor prognosis with the HRs of 1.29 (1.20,1.40), 1.13 (1.01,1.27), and 1.25 (1.08,1.44), respectively, while the fluid balance on days 4 and 5 had no effect on the primary outcome. Then RCSs showed an overall trend that the risk of in-hospital mortality on days 1, 2, and 3 increased with increasing fluid balance. For three consecutive days of fluid balance, we studied 9205 patients and Kaplan-Meier curves revealed survival differences among patients in the eight groups. The cox model demonstrated that compared with the "+/+/+" group, the "+/ -/-", "-/ -/-", "-/ -/+", "-/+/+", and "-/+/-" groups had a lower risk of in-hospital mortality, with HRs of 0.65 (0.45,0.93), 0.72 (0.60,0.86), 0.63 (0.43,0.93), 0.69 (0.48,0.98), and 0.63 (0.42,0.96), respectively.In patients with sepsis, positive fluid balance on days 1, 2, and 3 was associated with adverse outcomes. For patients with fluid balance for three consecutive days, the "+/-/-", "-/ -/-", "-/-/+", "-/+/+", and "-/+/-" groups were less likely to die in hospital than the "+/+/+" group.© 2021. The Author(s).

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区麻醉学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区麻醉学

第一作者：

第一作者机构： [1]Intensive Care Unit, The First Afliated Hospital of Jinan University, 510630 Guangzhou, Guangdong Province, People’s Republic of China [2]Department of Clinical Research, The First Afliated Hospital of Jinan University, Guangzhou, Guangdong Province, China

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Influence of fluid balance on the prognosis of patients with sepsis.

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