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Deciphering mechanism of the herbal formula WuShen in the treatment of postinfarction heart failure.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Qiu Huiliang[1,2,3,11] * ; Huang Zeng-Yan[4,5] * ; Cao Haiming[1,2,3] * ; Zhang Zezhao[1,2,3] ; Ma Jin[1,2,3] ; Li Xiao-Qing[1,2,3] ; Huang Shen[6] ; Li Xiong[1,3] ; Qiu Wencong[1,3] ; Zhao Zicong[7] ; Ji Chunlan[1,2,3] ; Huang Lihua[1,2,3] ; Jiang Wei[1,2,3,9] ; Yang Zhong-Qi[4,5] ; Xian Shao-Xiang[4,5] ; Wu Huanlin[1,2,3,8] ; Lu Weihui[1,2,3,*1] ; Ding Chunhua[1,2,10,*2] ;
机构： [1]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China [2]Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P.R. China [3]State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510020, P. R. China [4]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, P.R. China [5]Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, P.R. China [6]Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu 610081, P.R. China [7]Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, P.R. China [8]Department of internal medicine, Beijing University of Chinese Medicine, Beijing 100000, P.R. China [9]Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou 510020, P.R. China [10]Cardiac Department, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China [11]Division of Cardiology, University of California, San Francisco, San Francisco CA 94143, United States of America
出处：
DOI： 10.1016/j.phymed.2021.153878
ISSN：

关键词： Heart failure Arrhythmogenesis Adverse cardiac remodeling Upstream therapy Wushen Network pharmacology

摘要：
Numerous clinical studies reported the effectiveness of herbal formula WuShen (WS) in treating cardiovascular diseases, yet relevant basic research was rarely conducted.Twelve main bioactive compounds of WS decoction were identified using the ultra-performance liquid chromatography-LTQ-Orbitrap mass spectrometer. A total of 137 active compounds with 613 targets were predicted by network pharmacology; their bioinformatic annotation and human microarray data suggested that wounding healing, inflammatory response, and gap junction were potentially the major therapeutic modules. A rat model of post-myocardial infarction (MI) heart failure (HF) was used to study the effects of WS on cardiac function, adverse cardiac remodeling, and experimental arrhythmias. Rats treated with WS led to a significantly improved pump function and reduced susceptibility to both ventricular tachycardia and atrial fibrillation, and restricted adverse cardiac remodeling partly via inhibiting TGFβ1/SMADs mediated extracellular matrix deposition and Rac1/NOX2/CTGF/Connexin43 -involved gap junction remodeling.The present study highlights that WS can be applied to the treatment of heart failure and the upstream therapy for atrial fibrillation and ventricular tachycardia through its preventive effect on adverse cardiac remodeling.Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.

基金：
National Natural Science Foundation of China (No. 82074369 to Lu W), the Department of Science and Technology of Guangdong Province (No. 2014A020221045 to Huang S), the Guangdong Provincial Hospital of Chinese Medicine (No. YN2016MJ04 to Li XQ), the Science and Technology Planning Project of Guangdong Province (No. 2018B030322012), the Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine (No. SZ2021ZZ46 to Lu W), the Guangdong Province Talents Project in Colleges and Universities (No. 2050205 to Ding C), an Excellent Doctoral Dissertation Cultivation Project of the First Clinical Medical College of Guangzhou University of Chinese Medicine (No. YB201801 to Huang ZY), and a postdoc fellowship from American Heart Association to Qiu H (20POST35120455).
语种：
外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 1 区 植物科学 1 区 全科医学与补充医学 1 区 药学 2 区 药物化学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
JCR分区：
出版当年[2020]版：
Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 CHEMISTRY, MEDICINAL
最新[2023]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China [2]Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P.R. China [3]State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510020, P. R. China [11]Division of Cardiology, University of California, San Francisco, San Francisco CA 94143, United States of America
共同第一作者：
通讯作者：
通讯机构： [1]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China [2]Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P.R. China [3]State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510020, P. R. China [10]Cardiac Department, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China [*1]Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, 111 DaDe Rd, Guangzhou 510120, P.R. China [*2]Cardiac Department, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, 15 Yuquan Rd, Beijing 100049, P.R. China
推荐引用方式(GB/T 7714)：
Qiu Huiliang,Huang Zeng-Yan,Cao Haiming,et al.Deciphering mechanism of the herbal formula WuShen in the treatment of postinfarction heart failure.[J].PHYTOMEDICINE.2022,95:doi:10.1016/j.phymed.2021.153878.
APA：
Qiu Huiliang,Huang Zeng-Yan,Cao Haiming,Zhang Zezhao,Ma Jin...&Ding Chunhua.(2022).Deciphering mechanism of the herbal formula WuShen in the treatment of postinfarction heart failure..PHYTOMEDICINE,95,
MLA：
Qiu Huiliang,et al."Deciphering mechanism of the herbal formula WuShen in the treatment of postinfarction heart failure.".PHYTOMEDICINE 95.(2022)

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