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Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ EI

作者：
Mao, Shuai[1,2] * ; Wang, Lei[2] * ; Chen, Peipei[1,2] ; Lan, Yong[3] ; Guo, Rui[4,*2] ; Zhang, Minzhou[1,2,*1] ;
机构： [1]Key Discipline of Integrated Chinese and Western Medicine, Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China [2]AMI Key laboratory of Chinese Medicine in Guangzhou, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [3]Beogene Biotech (Guangzhou) CO., LTD, Guangzhou, China [4]Department of Biomedical Engineering, Jinan University, Guangzhou, China
出处：
DOI： 10.1080/21691401.2018.1508028
ISSN：

关键词： Nanoparticles cardiac remodeling tanshinone IIA myocardial infarctions NF-kappa B pathway

摘要：
Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic cardiac remodeling. However, the intrinsically poor solubility and bioavailability of tanshinone IIA hindered its clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-alpha-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating tanshinone IIA (tanshinone IIA-NPs) and study its efficacy in post-infarction left ventricular (LV) remodeling. Male C57BL/6 mice underwent left coronary artery ligation followed by subsequent intravenously injected tanshinone IIA-NPs therapy for 5 consecutive days. Treatment with tanshinone IIA-NP improved cardiac function, limited infarct expansion, and prevented left ventricle dilation at 4weeks post-MI. Furthermore, cardiomyocytes inflammation, apoptosis and myocardial fibrosis were significantly attenuated in tanshinone IIA-NP treated mice. These effects also correlated with inhibition of IB protein phosphorylation and NF-kappa B activation, leading to suppression of proinflammatory cytokine expression. Together, these results demonstrate tanshinone IIA-NP attenuated adverse cardiac remodeling and dysfunction mediated through prevention of IB phosphorylation and NF-kappa B activation. Tanshinone IIA-NP is a novel approach to treat myocardial IR injury in patients with MI.

基金：
National Science Foundation (81573708, 81703877, 81473471), National Basic Research Program of China (973 Program, 2015CB554400), Science Foundation of Guangdong Province (2015A030306049, 2015A030310437, 2014A030313402), Guangdong special support program for high-level talents (2015TQ01R588) and Medical Science and Technology Research Foundation of Guangdong Province (A2016192), the Science and Technology Program of Guangzhou (201601010270, 2017010160489, 201704030083), the Pearl River S&T Nova Program of Guangzhou (201710010155, 201806010072), and the Science and Technology Project of Guangdong province (2015A010101313, 2017A050506011, 2017A050501013, 2017B090911012).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 2 区 工程技术
小类 | 3 区 生物工程与应用微生物 3 区 工程：生物医学 4 区 材料科学：生物材料
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生物工程与应用微生物 3 区 工程：生物医学 3 区 材料科学：生物材料
JCR分区：
出版当年[2016]版：
Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 ENGINEERING, BIOMEDICAL
最新[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ENGINEERING, BIOMEDICAL Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Key Discipline of Integrated Chinese and Western Medicine, Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China [2]AMI Key laboratory of Chinese Medicine in Guangzhou, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Discipline of Integrated Chinese and Western Medicine, Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China [2]AMI Key laboratory of Chinese Medicine in Guangzhou, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [4]Department of Biomedical Engineering, Jinan University, Guangzhou, China [*1]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China [*2]Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
推荐引用方式(GB/T 7714)：
Mao Shuai,Wang Lei,Chen Peipei,et al.Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway[J].ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY.2018,46:S707-S716.doi:10.1080/21691401.2018.1508028.
APA：
Mao, Shuai,Wang, Lei,Chen, Peipei,Lan, Yong,Guo, Rui&Zhang, Minzhou.(2018).Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46,
MLA：
Mao, Shuai,et al."Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46.(2018):S707-S716

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