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CD38+ B cells affect immunotherapy for allergic rhinitis.

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机构： [1]Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, China. [2]Research Center of Ultrasonography, The Second Xiangya Hospital of Central South University, Changsha, China. [3]Department of Otorhinolaryngology-Head and Neck surgery, The first Hospital of Hunan University of Chinese Medicine, Changsha, China. [4]Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China. [5]Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Shenzhen, China. [6]Longgang E.N.T Hospital & Shenzhen E.N.T Institute, Shenzhen, China.

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关键词： Allergy immunotherapy CD38 B cell regulatory T cell

摘要：

Allergen specific immunotherapy (AIT) is the mainstay in the treatment of allergic diseases. Yet the therapeutic effects of AIT need to be improved. CD38+ B cells are an immune cell fraction involving in the pathogenesis of allergic diseases as well as in the immune regulation.background OBJECTIVES: To elucidate the role of antigen specific CD38+ B cells in AIT.An analysis was carried out on AIT results of 48 patients with perennial allergic rhinitis (AR), among which peripheral blood immune cells were analyzed by flow cytometry; serum cytokine levels were determined by ELISA. An AR murine model was developed to test the role of CD38+ B cells in AIT.A fraction of antigen-specific CD38+ B cell was detected in AR patients. CD38+ B cell frequency was negatively correlated with the therapeutic effects of AIT. A negative correlation was detected between the CD38+ B cell frequency and regulatory T cell frequency in AR patients treated with AIT. Exposure to specific antigens induced CD38+ B cells to produce IL-6, that converted Tregs to Th17 cells. Co-administration of anti-CD38 antibody significantly promoted the therapeutic effects of AIT.results CONCLUSIONS: Antigen-specific CD38+ B cells compromise the AIT effects by producing IL-6 to convert regulatory T cells to Th17 cells. Inhibition of CD38+ B cells promotes the effects of AIT.Copyright © 2022. Published by Elsevier Inc.

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出版当年[2021]版：

大类 | 1 区

医学

小类 | 1 区过敏 1 区免疫学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区过敏 1 区免疫学

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出版当年[2020]版：

Q1 IMMUNOLOGY Q1 ALLERGY

最新[2023]版：

Q1 ALLERGY Q1 IMMUNOLOGY

影响因子： 11.4 最新[2023版] 10.2 最新五年平均 10.793 出版当年[2020版] 13.181 出版当年五年平均 10.228 出版前一年[2019版] 14.29 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, China. [2]Research Center of Ultrasonography, The Second Xiangya Hospital of Central South University, Changsha, China.

通讯作者：

通讯机构： [3]Department of Otorhinolaryngology-Head and Neck surgery, The first Hospital of Hunan University of Chinese Medicine, Changsha, China. [4]Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China. [5]Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Shenzhen, China. [6]Longgang E.N.T Hospital & Shenzhen E.N.T Institute, Shenzhen, China. [*1]Department of Otorhinolaryngology-Head and Neck surgery, The first Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P. R. China [*2]Room A7-509, Lihu Campus, Shenzhen University School of Medicine. 1066 Xueyuan Blvd, Shenzhen 518055, China

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CD38+ B cells affect immunotherapy for allergic rhinitis.

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