Xiaoyao powder alleviates the hippocampal neuron damage in chronic unpredictable mild stress-induced depression model rats in hippocampus via connexin 43Cx43/glucocorticoid receptor/brain-derived neurotrophic factor signaling pathway.
机构：[1]South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou City, China.[2]Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou City, China.[3]The Forth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou City, China.[4]The 3rd Departments of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou City, China.[5]Department of Orthopaedics, Zhuhai People's Hospital, Zhuhai City, China.
Xiaoyao Powder (XYP) has been widely applied in China to treat stress-related illnesses, such as migraine, depression, Parkinson's disease, insomnia, and hypertension. Herein, this study aims to explore the effect of XYP on chronic unpredictable mild stress (CUMS)-induced depression and its underlying mechanisms. CUMS-induced depression rat models were established, they were subsequently randomly divided and treated with various conditions. Results of this study indicated that supplementation of XYP observably abolished CUMS-induced hippocampal damage and serum corticosterone (CORT) elevation. In mechanism, we discovered that CUMS induction could cause a prominent downregulation in glucocorticoid receptor (GR), phosphorylated-GR (p-GR), connexin 43 (Cx43), and brain-derived neurotrophic factor (BDNF), a remarkable upregulation in c-Src. While the introduction of XYP could reverse the changes in all of these indicators mediated by CUMS. Furthermore, we proved that Cx43 could interact with GR, and the protective effect of XYP on hippocampal neurons is realized by up-regulating GR. Summarized, this study indicated that XYP could ameliorate hippocampal neuron damage in CUMS-induced depression model rats through acting on Cx43/GR/BDNF axis.
基金：
Project of Administration of Traditional Chinese Medicine of Guangdong Province of China (20201419), Guangdong Province Science and Technology Plan Project (2021A1515410001), ShenZhen Science and Technology Planning Project (JCYJ20190812163201666).
第一作者机构：[1]South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou City, China.
通讯作者：
通讯机构：[4]The 3rd Departments of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou City, China.[5]Department of Orthopaedics, Zhuhai People's Hospital, Zhuhai City, China.[*1]No. 578, Shatai South Road, Baiyun District, Guangzhou, 510510 China[*2]No. 79, Kangning Road, Zhuhai, 519000 China
推荐引用方式(GB/T 7714)：
Zhang Yuanyuan,Luo Yong,Hou Xuenan,et al.Xiaoyao powder alleviates the hippocampal neuron damage in chronic unpredictable mild stress-induced depression model rats in hippocampus via connexin 43Cx43/glucocorticoid receptor/brain-derived neurotrophic factor signaling pathway.[J].BIOENGINEERED.2022,13(1):383-394.doi:10.1080/21655979.2021.2005744.
APA：
Zhang Yuanyuan,Luo Yong,Hou Xuenan,Lu Kang,He Yanhong...&Qin Yi.(2022).Xiaoyao powder alleviates the hippocampal neuron damage in chronic unpredictable mild stress-induced depression model rats in hippocampus via connexin 43Cx43/glucocorticoid receptor/brain-derived neurotrophic factor signaling pathway..BIOENGINEERED,13,(1)
MLA：
Zhang Yuanyuan,et al."Xiaoyao powder alleviates the hippocampal neuron damage in chronic unpredictable mild stress-induced depression model rats in hippocampus via connexin 43Cx43/glucocorticoid receptor/brain-derived neurotrophic factor signaling pathway.".BIOENGINEERED 13..1(2022):383-394
