机构：[1]Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseaseand National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou,China[2]Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Laboratory ofSouth China Structural Heart Disease, Guangzhou, China广东省人民医院[3]Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China珠海院区广东省中医院[4]Huizhou FirstHospital, Huizhou, China[5]The First Affiliated Hospital of Shantou University Medical College, Shantou, China[6]The First Affiliated Hospitalof Guangdong Pharmaceutical University, Guangzhou, China[7]The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China中山大学附属第一医院[8]ShundeHospital of Southern Medical University, Foshan, China[9]Shunde Hospital Guangzhou University of Chinese Medicine (Shunde District Hospital ofChinese Medicine of Foshan City), Foshan, China[10]The Third Affiliated Hospital of Sun Yat-sen University- Lingnan Hospital, Guangzhou, China中山大学附属第三医院[11]Zhongshan People’s Hospital, Zhongshan, China[12]Foresea Life Insurance Guangzhou General Hospital, Guangzhou, China[13]Guangzhou panyuCentral Hospital, Guangzhou, China[14]The Third Affiliated Hospital of Southern Medical University, Guangzhou, China[15]The Third AffiliatedHospital of Sun Yat-sen University, Guangzhou, China[16]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou,China[17]The First Affiliated Hospital of Jinan University, Guangzhou, China
Background: Mechanical ventilation (MV) is an important lifesaving method in intensive care unit (ICU). Prolonged MV is associated with VAP and other complications. However, premature weaning from MV may lead to higher risk of reintubation or mortality. Therefore, timely and safe weaning from MV is important. In addition, identification of the right patient and performing a suitable weaning process is necessary. Although several guidelines about weaning have been reported, compliance with these guidelines is unknown. Therefore, the aim of this study is to explore the variation of weaning in China, associations between initial MV reason and clinical outcomes, and factors associated with weaning strategies using a multicenter cohort. Methods: This multicenter retrospective cohort study will be conducted at 17 adult ICUs in China, that included patients who were admitted in this 17 ICUs between October 2020 and February 2021. Patients under 18 years of age and patients without the possibility for weaning will be excluded. The questionnaire information will be registered by a specific clinician in each center who has been evaluated and qualified to carry out the study. Discussion: In a previous observational study of weaning in 17 ICUs in China, weaning practices varies nationally. Therefore, a multicenter retrospective cohort study is necessary to be conducted to explore the present weaning methods used in China. Trial Registration: Chinese Clinical Trial Registry (ChiCTR) (No. ChiCTR2100044634).
基金：
Emergency Key
Program of Guangzhou Laboratory (Grant No. EKPG21-
17), National Natural Science Funds of China (Grant
No. 81900285), Science and Technology Program of
Guangzhou, China (Grant No. 202002030317), The Special
Project of Guangdong Science and Technology Department
(2020B1111340016) and Guangdong Basic and Applied
Basic Research Foundation (Grant No. 2020A1515010242).
第一作者机构：[1]Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseaseand National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou,China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseaseand National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou,China[15]The Third AffiliatedHospital of Sun Yat-sen University, Guangzhou, China[*1]Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China.[*2]Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China.[*3]The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou 510000, China.
推荐引用方式(GB/T 7714)：
Yingzhi Wang,Liming Lei,Huawei Yang,et al.Weaning critically ill patients from mechanical ventilation: a protocol from a multicenter retrospective cohort study[J].JOURNAL OF THORACIC DISEASE.2022,14(1):199-+.doi:10.21037/jtd-21-1217.
APA：
Yingzhi Wang,Liming Lei,Huawei Yang,Songbin He,Junhai Hao...&Kouxing Zhang.(2022).Weaning critically ill patients from mechanical ventilation: a protocol from a multicenter retrospective cohort study.JOURNAL OF THORACIC DISEASE,14,(1)
MLA：
Yingzhi Wang,et al."Weaning critically ill patients from mechanical ventilation: a protocol from a multicenter retrospective cohort study".JOURNAL OF THORACIC DISEASE 14..1(2022):199-+
